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PMID: 15173891 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.

The Journal of clinical investigation ·Vol. 113 ·No. 11 ·2004-06-00 ·Pages 1641-50

Liliensiek B, Weigand MA, Bierhaus A, Nicklas W, Kasper M, Hofer S, Plachky J, Gröne HJ, Kurschus FC, Schmidt AM, Yan SD, Martin E, Schleicher E, Stern DM, Hämmerling G Gü, Nawroth PP, Arnold B

Abstract

While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.

MeSH Terms
Animals Cecum/injuries Immune System/immunology,metabolism Mice Mice, Knockout Peritonitis/metabolism Receptor for Advanced Glycation End Products Receptors, Immunologic/genetics,immunology,metabolism Sepsis/metabolism Shock, Septic/metabolism Time Factors
Chemicals
Receptor for Advanced Glycation End Products Receptors, Immunologic
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Liliensiek Birgit
Department of Molecular Immunology, Division of Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.
Weigand Markus A
Bierhaus Angelika
Nicklas Werner
Kasper Michael
Hofer Stefan
Plachky Jens
Gröne Herman-Josef
Kurschus Florian C
Schmidt Ann Marie
Yan Shi Du
Martin Eike
Schleicher Erwin
Stern David M
Hämmerling G G ünterJ
Nawroth Peter P
Arnold Bernd
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI18704
Published
2004-06-00
Pages
1641-50
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC419481
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI18704 PMC Full Text View journal details
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