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Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells.
Infect Immun. 2000 Jan;68(1):113-9
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Lipoproteins take their toll on the host.
Curr Biol. 1999 Dec 2;9(23):R879-82
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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.
J Immunol. 2000 Jan 15;164(2):558-61
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Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells.
J Biol Chem. 2000 Jan 21;275(3):2071-9
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Toll signaling pathways in the innate immune response.
Curr Opin Immunol. 2000 Feb;12(1):13-9
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Tlr4: central component of the sole mammalian LPS sensor.
Curr Opin Immunol. 2000 Feb;12(1):20-6
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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
J Clin Invest. 2000 Feb;105(4):497-504
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Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2163-7
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Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system.
Mol Microbiol. 2000 Mar;35(5):991-1004
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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.
Nat Med. 2000 Apr;6(4):435-42
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TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.
Mol Cell Biol. 2000 May;20(9):3015-26
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The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity.
J Biol Chem. 2000 Apr 21;275(16):12102-7
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Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes.
J Leukoc Biol. 2000 Apr;67(4):450-6
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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
Nat Genet. 2000 Jun;25(2):187-91
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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Annu Rev Immunol. 2000;18:621-63
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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Mol Cell. 2000 Apr;5(4):649-58
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The apoptotic signaling pathway activated by Toll-like receptor-2.
EMBO J. 2000 Jul 3;19(13):3325-36
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Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.
J Immunol. 2000 Jul 15;165(2):618-22
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Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.
J Biol Chem. 2000 Jul 7;275(27):20861-6
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Hostile takeovers: viral appropriation of the NF-kappaB pathway.
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Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin.
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The instructive role of innate immunity in the acquired immune response.
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A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.
Genes Dev. 1996 Nov 1;10(21):2745-58
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A conserved signaling pathway: the Drosophila toll-dorsal pathway.
Annu Rev Cell Dev Biol. 1996;12:393-416
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An IkappaB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages.
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Innate immunity: impact on the adaptive immune response.
Curr Opin Immunol. 1997 Feb;9(1):4-9
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Signaling in plant-microbe interactions.
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
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Immunol Today. 1998 Feb;19(2):80-8
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Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.
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A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression.
Mol Cell Biol. 1998 Jun;18(6):3527-39
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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Annu Rev Immunol. 1998;16:225-60
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Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
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LPS-binding proteins and receptors.
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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.
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Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide.
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A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase.
Curr Biol. 1999 Jan 28;9(2):101-4
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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Nature. 1999 Mar 18;398(6724):252-6
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Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
J Immunol. 1999 Apr 1;162(7):3749-52
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Phylogenetic perspectives in innate immunity.
Science. 1999 May 21;284(5418):1313-8
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Tumor necrosis factor receptor and Fas signaling mechanisms.
Annu Rev Immunol. 1999;17:331-67
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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
J Exp Med. 1999 Jun 7;189(11):1777-82
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Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.
J Immunol. 1999 Jul 15;163(2):639-43
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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Science. 1999 Jul 30;285(5428):732-6
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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
Science. 1999 Jul 30;285(5428):736-9
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Unresponsiveness of MyD88-deficient mice to endotoxin.
Immunity. 1999 Jul;11(1):115-22
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ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
Genes Dev. 1999 Aug 15;13(16):2059-71
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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity. 1999 Oct;11(4):443-51
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Control of apoptosis by Rel/NF-kappaB transcription factors.
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