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PMID: 11134172 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.

The Journal of clinical investigation ·Vol. 107 ·No. 1 ·2001-01-00 ·Pages 13-9

Zhang G, Ghosh S

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Animals Conserved Sequence Humans Immunity, Innate Lipopolysaccharide Receptors/metabolism Molecular Sequence Data NF-kappa B/metabolism Phylogeny Proto-Oncogene Proteins c-rel/metabolism Receptors, Cell Surface/genetics,metabolism Signal Transduction
Chemicals
Lipopolysaccharide Receptors NF-kappa B Proto-Oncogene Proteins c-rel Receptors, Cell Surface
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zhang G
Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.
Ghosh S
References (49)
49 references, click to expand
  1. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells.
    Infect Immun. 2000 Jan;68(1):113-9 PMID: 10603376
  2. Lipoproteins take their toll on the host.
    Curr Biol. 1999 Dec 2;9(23):R879-82 PMID: 10607553
  3. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.
    J Immunol. 2000 Jan 15;164(2):558-61 PMID: 10623794
  4. Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells.
    J Biol Chem. 2000 Jan 21;275(3):2071-9 PMID: 10636911
  5. Toll signaling pathways in the innate immune response.
    Curr Opin Immunol. 2000 Feb;12(1):13-9 PMID: 10679407
  6. Tlr4: central component of the sole mammalian LPS sensor.
    Curr Opin Immunol. 2000 Feb;12(1):20-6 PMID: 10679411
  7. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
    J Clin Invest. 2000 Feb;105(4):497-504 PMID: 10683379
  8. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
    Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2163-7 PMID: 10681462
  9. Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system.
    Mol Microbiol. 2000 Mar;35(5):991-1004 PMID: 10712682
  10. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.
    Nat Med. 2000 Apr;6(4):435-42 PMID: 10742151
  11. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.
    Mol Cell Biol. 2000 May;20(9):3015-26 PMID: 10757786
  12. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity.
    J Biol Chem. 2000 Apr 21;275(16):12102-7 PMID: 10766844
  13. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes.
    J Leukoc Biol. 2000 Apr;67(4):450-6 PMID: 10770275
  14. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
    Nat Genet. 2000 Jun;25(2):187-91 PMID: 10835634
  15. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
    Annu Rev Immunol. 2000;18:621-63 PMID: 10837071
  16. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
    Mol Cell. 2000 Apr;5(4):649-58 PMID: 10882101
  17. The apoptotic signaling pathway activated by Toll-like receptor-2.
    EMBO J. 2000 Jul 3;19(13):3325-36 PMID: 10880445
  18. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.
    J Immunol. 2000 Jul 15;165(2):618-22 PMID: 10878331
  19. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.
    J Biol Chem. 2000 Jul 7;275(27):20861-6 PMID: 10877845
  20. Hostile takeovers: viral appropriation of the NF-kappaB pathway.
    J Clin Invest. 2001 Jan;107(2):143-51 PMID: 11160127
  21. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin.
    Annu Rev Immunol. 1995;13:437-57 PMID: 7542010
  22. The instructive role of innate immunity in the acquired immune response.
    Science. 1996 Apr 5;272(5258):50-3 PMID: 8600536
  23. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.
    Genes Dev. 1996 Nov 1;10(21):2745-58 PMID: 8946915
  24. A conserved signaling pathway: the Drosophila toll-dorsal pathway.
    Annu Rev Cell Dev Biol. 1996;12:393-416 PMID: 8970732
  25. An IkappaB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages.
    J Virol. 1996 Dec;70(12):8527-33 PMID: 8970976
  26. Innate immunity: impact on the adaptive immune response.
    Curr Opin Immunol. 1997 Feb;9(1):4-9 PMID: 9039775
  27. Signaling in plant-microbe interactions.
    Science. 1997 May 2;276(5313):726-33 PMID: 9115193
  28. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
    Nature. 1997 Jul 24;388(6640):394-7 PMID: 9237759
  29. Signal transduction through NF-kappa B.
    Immunol Today. 1998 Feb;19(2):80-8 PMID: 9509763
  30. Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production.
    J Exp Med. 1998 Apr 6;187(7):1069-79 PMID: 9529323
  31. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression.
    Mol Cell Biol. 1998 Jun;18(6):3527-39 PMID: 9584193
  32. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
    Annu Rev Immunol. 1998;16:225-60 PMID: 9597130
  33. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
    J Leukoc Biol. 1998 Jun;63(6):650-7 PMID: 9620655
  34. LPS-binding proteins and receptors.
    J Leukoc Biol. 1998 Jul;64(1):25-32 PMID: 9665271
  35. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.
    Nature. 1998 Sep 17;395(6699):284-8 PMID: 9751057
  36. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide.
    J Exp Med. 1998 Dec 7;188(11):2091-7 PMID: 9841923
  37. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase.
    Curr Biol. 1999 Jan 28;9(2):101-4 PMID: 10021364
  38. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
    Nature. 1999 Mar 18;398(6724):252-6 PMID: 10094049
  39. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
    J Immunol. 1999 Apr 1;162(7):3749-52 PMID: 10201887
  40. Phylogenetic perspectives in innate immunity.
    Science. 1999 May 21;284(5418):1313-8 PMID: 10334979
  41. Tumor necrosis factor receptor and Fas signaling mechanisms.
    Annu Rev Immunol. 1999;17:331-67 PMID: 10358762
  42. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
    J Exp Med. 1999 Jun 7;189(11):1777-82 PMID: 10359581
  43. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.
    J Immunol. 1999 Jul 15;163(2):639-43 PMID: 10395652
  44. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
    Science. 1999 Jul 30;285(5428):732-6 PMID: 10426995
  45. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
    Science. 1999 Jul 30;285(5428):736-9 PMID: 10426996
  46. Unresponsiveness of MyD88-deficient mice to endotoxin.
    Immunity. 1999 Jul;11(1):115-22 PMID: 10435584
  47. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
    Genes Dev. 1999 Aug 15;13(16):2059-71 PMID: 10465784
  48. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
    Immunity. 1999 Oct;11(4):443-51 PMID: 10549626
  49. Control of apoptosis by Rel/NF-kappaB transcription factors.
    Oncogene. 1999 Nov 22;18(49):6910-24 PMID: 10602466
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
2001-01-00
Pages
13-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC198554
Subset
IM
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