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PMID: 2014247 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 8 ·1991-04-15 ·Pages 3243-7

Love DR, Morris GE, Ellis JM, Fairbrother U, Marsden RF, Bloomfield JF, Edwards YH, Slater CP, Parry DJ, Davies KE

Abstract

We have previously reported a dystrophin-related locus (DMDL for Duchenne muscular dystrophy-like) on human chromosome 6 that maps close to the dy mutation on mouse chromosome 10. Here we show that this gene is expressed in a wide range of tissues at varying levels. The transcript is particularly abundant in several human fetal tissues, including heart, placenta, and intestine. Studies with antisera raised against a DMDL fusion protein identify a 400,000 Mr protein in all mouse tissues tested, including those of mdx and dy mice. Unlike the dystrophin gene, the DMDL gene transcript is not differentially spliced at the 3' end in either fetal muscle or brain.

Related Genes
DMDL Dmdl
MeSH Terms
Animals Blotting, Northern Blotting, Western Dystrophin/genetics Humans Liver/metabolism Mice Mice, Mutant Strains Muscle Proteins/genetics,immunology,metabolism Muscles/metabolism Muscular Dystrophy, Animal/genetics Polymerase Chain Reaction RNA Splicing RNA, Messenger/metabolism Sequence Homology, Nucleic Acid Species Specificity Tissue Distribution
Chemicals
Dystrophin Muscle Proteins RNA, Messenger
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Love D R
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
Morris G E
Ellis J M
Fairbrother U
Marsden R F
Bloomfield J F
Edwards Y H
Slater C P
Parry D J
Davies K E
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33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.8.3243
Published
1991-04-15
Pages
3243-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51422
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.88.8.3243 PMC Full Text View journal details
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