Home LiteratureArticle Details
PMID: 2014262 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 8 ·1991-04-15 ·Pages 3412-5

Rotello RJ, Lieberman RC, Purchio AF, Gerschenson LE

Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

MeSH Terms
Animals Cell Division/drug effects Cell Survival/drug effects Cells, Cultured DNA Damage/drug effects Epithelial Cells Female In Vitro Techniques Nucleosomes/ultrastructure Rabbits Recombinant Proteins Transforming Growth Factor beta/pharmacology Uterus/cytology
Chemicals
Nucleosomes Recombinant Proteins Transforming Growth Factor beta
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rotello R J
Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Lieberman R C
Purchio A F
Gerschenson L E
References (28)
28 references, click to expand
  1. Death in embryonic systems.
    Science. 1966 Nov 4;154(3749):604-12 PMID: 5332319
  2. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes.
    Nature. 1989 Jun 22;339(6226):625-6 PMID: 2786609
  3. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis.
    Nature. 1990 Jan 4;343(6253):76-9 PMID: 1688645
  4. Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids.
    Proc Natl Acad Sci U S A. 1990 Jul;87(14):5543-7 PMID: 2371287
  5. Further studies on the regulation of cultured rabbit endometrial cells by diethylstilbestrol and progesterone.
    J Steroid Biochem. 1976 Mar;7(3):159-65 PMID: 180332
  6. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.
    Nature. 1980 Apr 10;284(5756):555-6 PMID: 6245367
  7. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.
    Science. 1983 Jun 17;220(4603):1277-9 PMID: 6857247
  8. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
    J Immunol. 1984 Jan;132(1):38-42 PMID: 6317746
  9. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.
    J Pathol. 1984 Jan;142(1):67-77 PMID: 6422024
  10. Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid.
    Endocrinology. 1986 Jan;118(1):38-45 PMID: 3940853
  11. Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.
    Cancer Res. 1986 Apr;46(4 Pt 2):2068-71 PMID: 2418960
  12. Genetic control of programmed cell death in the nematode C. elegans.
    Cell. 1986 Mar 28;44(6):817-29 PMID: 3955651
  13. Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.
    Proc Natl Acad Sci U S A. 1986 Apr;83(8):2438-42 PMID: 2871553
  14. Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells.
    Cell. 1986 Jun 6;45(5):685-98 PMID: 3754790
  15. Steroid control of neuron and muscle development during the metamorphosis of an insect.
    J Neurobiol. 1986 May;17(3):249-67 PMID: 3519866
  16. Evidence for soluble factors regulating cell death and cell proliferation in primary cultures of rabbit endometrial cells grown on collagen.
    Proc Natl Acad Sci U S A. 1986 Jul;83(13):4784-8 PMID: 3460073
  17. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.
    Lymphokine Res. 1986 Fall;5(4):289-99 PMID: 2946903
  18. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells.
    Cell. 1987 Feb 13;48(3):417-28 PMID: 2879636
  19. Reversible inhibition of mammary gland growth by transforming growth factor-beta.
    Science. 1987 Jul 17;237(4812):291-3 PMID: 3474783
  20. Some recent advances in the chemistry and biology of transforming growth factor-beta.
    J Cell Biol. 1987 Sep;105(3):1039-45 PMID: 3308901
  21. Role of transforming growth factor-beta in the development of the mouse embryo.
    J Cell Biol. 1987 Dec;105(6 Pt 2):2861-76 PMID: 3320058
  22. Activation of programmed cell death in the rat ventral prostate after castration.
    Endocrinology. 1988 Feb;122(2):552-62 PMID: 2828003
  23. Transforming growth factor-beta s are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation.
    Cell Immunol. 1988 Jun;114(1):41-54 PMID: 2897247
  24. Localized cell death caused by mutations in a Drosophila gene coding for a transforming growth factor-beta homolog.
    Dev Biol. 1988 Aug;128(2):386-95 PMID: 3165073
  25. 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
    Science. 1988 Oct 14;242(4876):256-9 PMID: 3262923
  26. Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.
    Mol Cell Biol. 1988 Oct;8(10):4162-8 PMID: 3185545
  27. Biochemical evidence for programmed cell death in rabbit uterine epithelium.
    Am J Pathol. 1989 Mar;134(3):491-5 PMID: 2923180
  28. Expression of transforming growth factor-beta in the rat ventral prostate during castration-induced programmed cell death.
    Mol Endocrinol. 1989 Oct;3(10):1515-22 PMID: 2608047
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.8.3412
Published
1991-04-15
Pages
3412-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51457
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.88.8.3412 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2