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PMID: 20142834 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Establishing, maintaining and modifying DNA methylation patterns in plants and animals.

Nature reviews. Genetics ·Vol. 11 ·No. 3 ·2010-03-00 ·Pages 204-20

Law JA, Jacobsen SE

Abstract

Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. Recent findings in plants and animals have greatly increased our understanding of the pathways used to accurately target, maintain and modify patterns of DNA methylation and have revealed unanticipated mechanistic similarities between these organisms. Key roles have emerged for small RNAs, proteins with domains that bind methylated DNA and DNA glycosylases in these processes. Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation.

MeSH Terms
Animals CpG Islands DNA Methylation/genetics,physiology DNA, Plant/genetics,metabolism Epigenesis, Genetic Gametogenesis/genetics Histones/genetics,metabolism Models, Genetic Plants/genetics,metabolism RNA, Small Interfering/genetics,metabolism
Chemicals
DNA, Plant Histones RNA, Small Interfering
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Law Julie A
Department of Molecular, Cell and Developmental Biology, University of California-Los Angeles, 90095-1606, USA.
Jacobsen Steven E
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2719
Published
2010-03-00
Pages
204-20
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3034103
Subset
IM
Grants
NIGMS NIH HHS · R37 GM060398 · United States
NIGMS NIH HHS · R37 GM060398-10 · United States
NIGMS NIH HHS · GM60398 · United States
NIGMS NIH HHS · 5F32GM820453 · United States
External Links
PubMed source DOI: 10.1038/nrg2719 PMC Full Text View journal details
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