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PMID: 20195253 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Visualization of multiple alignments, phylogenies and gene family evolution.

Nature methods ·Vol. 7 ·No. 3 Suppl ·2010-03-00 ·Pages S16-25

Procter JB, Thompson J, Letunic I, Creevey C, Jossinet F, Barton GJ

Abstract

Software for visualizing sequence alignments and trees are essential tools for life scientists. In this review, we describe the major features and capabilities of a selection of stand-alone and web-based applications useful when investigating the function and evolution of a gene family. These range from simple viewers, to systems that provide sophisticated editing and analysis functions. We conclude with a discussion of the challenges that these tools now face due to the flood of next generation sequence data and the increasingly complex network of bioinformatics information sources.

MeSH Terms
Amino Acid Sequence Biological Evolution Internet Molecular Sequence Data Multigene Family Phylogeny Proteins/chemistry Sequence Alignment Sequence Homology, Amino Acid
Chemicals
Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Procter James B
University of Dundee, UK. [email protected]
Thompson Julie
Letunic Ivica
Creevey Chris
Jossinet Fabrice
Barton Geoffrey J
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Article Info
Journal
Nature methods
Abbr.
Nat Methods
ISSN
1548-7105
DOI
10.1038/nmeth.1434
Email
[email protected]
Published
2010-03-00
Pages
S16-25
Language
English
Region
United States
NLM ID
101215604
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/G022682/1 · United Kingdom
External Links
PubMed source DOI: 10.1038/nmeth.1434 View journal details
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