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PMID: 20362426 Published · ppublish English Journal Article Review

RNA traffic control of chromatin complexes.

Current opinion in genetics & development ·Vol. 20 ·No. 2 ·2010-04-00 ·Pages 142-8

Koziol MJ, Rinn JL

Abstract

It is widely accepted that the genome is regulated by histone modifications that induce epigenetic changes on the genome. However, it is still not understood how ubiquitously expressed chromatin modifying complexes are 'guided' to specific genomic sites to induce intricate patterns of epigenetic modifications. Previously believed to represent 'genome junk', it is now becoming increasingly clear that large non-coding RNAs associate with chromatin modifying complexes. Here we explore an intriguing hypothesis that large non-coding RNA molecules might represent a molecular trafficking system that modulates chromatin modifying complexes to establish specific epigenetic landscapes.

MeSH Terms
Animals Chromatin/metabolism Epigenesis, Genetic/genetics Gene Expression Regulation Genomic Imprinting Homeodomain Proteins/genetics Humans Models, Genetic RNA, Untranslated/genetics,metabolism X Chromosome Inactivation
Chemicals
Chromatin Homeodomain Proteins RNA, Untranslated
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Koziol Magdalena J
BIDMC Department of Pathology, Harvard Medical School, Boston, MA 02215, United States.
Rinn John L
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Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
1879-0380
DOI
10.1016/j.gde.2010.03.003
Published
2010-04-00
Epub
2010-00-31
Pages
142-8
Language
English
Region
England
NLM ID
9111375
PMCID
PMC2895502
Subset
IM
Grants
NIH HHS · DP2 OD006670 · United States
NIH HHS · DP2 OD006670-01 · United States
External Links
PubMed source DOI: 10.1016/j.gde.2010.03.003 PMC Full Text View journal details
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