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PMID: 20409276 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

The ubiquitin-proteasome system regulates plant hormone signaling.

The Plant journal : for cell and molecular biology ·Vol. 61 ·No. 6 ·2010-03-00 ·Pages 1029-40

Santner A, Estelle M

Abstract

Plants utilize the ubiquitin-proteasome system (UPS) to modulate nearly every aspect of growth and development. Ubiquitin is covalently attached to target proteins through the action of three enzymes known as E1, E2, and E3. The ultimate outcome of this post-translational modification depends on the nature of the ubiquitin linkage and the extent of polyubiquitination. In most cases, ubiquitination results in degradation of the target protein in the 26S proteasome. During the last 10 years it has become clear that the UPS plays a prominent regulatory role in hormone biology. E3 ubiquitin ligases in particular actively participate in hormone perception, de-repression of hormone signaling pathways, degradation of hormone specific transcription factors, and regulation of hormone biosynthesis. It is certain that additional functions will be discovered as more of the nearly 1200 potential E3s in plants are elucidated.

MeSH Terms
Plant Growth Regulators/physiology Plants/metabolism Proteasome Endopeptidase Complex/physiology Protein Processing, Post-Translational Ubiquitin/physiology Ubiquitin-Protein Ligases/physiology Ubiquitination
Chemicals
Plant Growth Regulators Ubiquitin Ubiquitin-Protein Ligases Proteasome Endopeptidase Complex
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Santner Aaron
Molecular Kinetics, Inc., 6201 La Pas Trail, Suite 160, Indianapolis, IN 46268, USA.
Estelle Mark
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Article Info
Journal
The Plant journal : for cell and molecular biology
Abbr.
Plant J
ISSN
1365-313X
DOI
10.1111/j.1365-313X.2010.04112.x
Published
2010-03-00
Pages
1029-40
Language
English
Region
England
NLM ID
9207397
PMCID
PMC3066055
Subset
IM
Grants
NIGMS NIH HHS · R01 GM043644 · United States
NIGMS NIH HHS · R01 GM043644-24 · United States
NIGMS NIH HHS · GM43644 · United States
External Links
PubMed source DOI: 10.1111/j.1365-313X.2010.04112.x PMC Full Text View journal details
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