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PMID: 20414256 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The nuclear envelope in genome organization, expression and stability.

Nature reviews. Molecular cell biology ·Vol. 11 ·No. 5 ·2010-05-00 ·Pages 317-28

Mekhail K, Moazed D

Abstract

Non-random positioning of chromosomal domains relative to each other and to nuclear landmarks is a common feature of eukaryotic genomes. In particular, the distribution of DNA loci relative to the nuclear periphery has been linked to both transcriptional activation and repression. Nuclear pores and other integral membrane protein complexes are key players in the dynamic organization of the genome in the nucleus, and recent advances in our understanding of the molecular networks that organize genomes at the nuclear periphery point to a further role for non-random locus positioning in DNA repair, recombination and stability.

MeSH Terms
Animals Cytoskeleton/metabolism DNA/metabolism Gene Expression Regulation Genome/genetics Genomic Instability Humans Nuclear Envelope/metabolism
Chemicals
DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mekhail Karim
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada. [email protected]
Moazed Danesh
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2894
Email
[email protected]
Published
2010-05-00
Pages
317-28
Language
English
Region
England
NLM ID
100962782
PMCID
PMC3246372
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM061641 · United States
NIGMS NIH HHS · R01 GM061641-11 · United States
CIHR · Canada
External Links
PubMed source DOI: 10.1038/nrm2894 PMC Full Text View journal details
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