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PMID: 20471718 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment.

Neurobiology of aging ·Vol. 33 ·No. 2 ·2012-02-00 ·Pages 242-53

McDonald CR, Gharapetian L, McEvoy LK, Fennema-Notestine C, Hagler DJ, Holland D, Dale AM, Alzheimer's Disease Neuroimaging Initiative

Abstract

We investigated the relationship between regional atrophy rates and 2-year cognitive decline in a large cohort of patients with mild cognitive impairment (MCI; n = 103) and healthy controls (n = 90). Longitudinal magnetic resonance image (MRI) scans were analyzed using high-throughput image analysis procedures. Atrophy rates were derived by calculating percent cortical volume loss between baseline and 24 month scans. Stepwise regressions were performed to investigate the contribution of atrophy rates to language, memory, and executive functioning decline, controlling for age, gender, baseline performances, and disease progression. In MCI, left temporal lobe atrophy rates were associated with naming decline, whereas bilateral temporal, left frontal, and left anterior cingulate atrophy rates were associated with semantic fluency decline. Left entorhinal atrophy rate was associated with memory decline and bilateral frontal atrophy rates were associated with executive function decline. These data provide evidence that regional atrophy rates in MCI contribute to domain-specific cognitive decline, which appears to be partially independent of disease progression. MRI measures of regional atrophy can provide valuable information for understanding the neural basis of cognitive impairment in MCI.

MeSH Terms
Aged Atrophy/pathology Brain/pathology Cognition Disorders/pathology Female Humans Magnetic Resonance Imaging/methods Male Statistics as Topic
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
McDonald Carrie R
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. [email protected]
Gharapetian Lusineh
McEvoy Linda K
Fennema-Notestine Christine
Hagler Donald J
Holland Dominic
Dale Anders M
Alzheimer's Disease Neuroimaging Initiative
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Article Info
Journal
Neurobiology of aging
Abbr.
Neurobiol Aging
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2010.03.015
Email
[email protected]
Published
2012-02-00
Epub
2010-00-14
Pages
242-53
Language
English
Region
United States
NLM ID
8100437
PMCID
PMC2923665
Subset
IM
Grants
NCRR NIH HHS · U24 RR021382 · United States
NINDS NIH HHS · K23 NS056091 · United States
NIA NIH HHS · K01 AG029218 · United States
NIA NIH HHS · U01 AG024904 · United States
NINDS NIH HHS · K23 NS056091-04 · United States
External Links
PubMed source DOI: 10.1016/j.neurobiolaging.2010.03.015 PMC Full Text View journal details
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