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PMID: 20519313 Published · ppublish English Journal Article Review

The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.

The Journal of physiology ·Vol. 588 ·No. Pt 17 ·2010-09-01 ·Pages 3201-9

McTaggart JS, Clark RH, Ashcroft FM

Abstract

ATP-sensitive potassium (K(ATP)) channels are critical for the maintenance of glucose homeostasis. They are essential for glucose-stimulated insulin secretion from pancreatic beta-cells, contribute to the mechanisms by which hypoglycaemia stimulates glucagon release from pancreatic alpha-cells, and are involved in glucose uptake into skeletal muscle, glucose production and release from the liver, and feeding behaviour. Not surprisingly, loss- or gain-of-function mutations in K(ATP) channel genes have profound effects, giving rise to congenital hyperinsulinaemia and neonatal diabetes respectively. This symposium review focuses on our current understanding of the role of the K(ATP) channel in glucose homeostasis in health and disease.

MeSH Terms
Animals Blood Glucose/chemistry,metabolism,physiology Diabetes Mellitus/metabolism,pathology,physiopathology Health Status Homeostasis/physiology Humans Hyperinsulinism/metabolism,pathology,physiopathology Islets of Langerhans/chemistry,metabolism,physiology KATP Channels/chemistry,physiology
Chemicals
Blood Glucose KATP Channels
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McTaggart James S
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, and OXION Centre for Ion Channel Studies, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.
Clark Rebecca H
Ashcroft Frances M
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
1469-7793
DOI
10.1113/jphysiol.2010.191767
Published
2010-09-01
Epub
2010-00-02
Pages
3201-9
Language
English
Region
England
NLM ID
0266262
PMCID
PMC2976015
Subset
IM
Grants
Wellcome Trust · 084655 · United Kingdom
External Links
PubMed source DOI: 10.1113/jphysiol.2010.191767 PMC Full Text View journal details
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