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PMID: 20638636 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Inflammasome inhibition as a pathogenic stealth mechanism.

Cell host & microbe ·Vol. 8 ·No. 1 ·2010-07-22 ·Pages 7-11

Taxman DJ, Huang MT, Ting JP

Abstract

The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.

MeSH Terms
Animals Bacteria/immunology,pathogenicity Bacterial Infections/immunology,microbiology Down-Regulation Host-Pathogen Interactions Humans Virus Diseases/immunology,virology Viruses/immunology,pathogenicity
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taxman Debra J
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
Huang Max T-H
Ting Jenny P-Y
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Article Info
Journal
Cell host & microbe
Abbr.
Cell Host Microbe
ISSN
1934-6069
DOI
10.1016/j.chom.2010.06.005
Published
2010-07-22
Pages
7-11
Language
English
Region
United States
NLM ID
101302316
PMCID
PMC2911019
Subset
IM
Grants
NIDCR NIH HHS · R01-DE016326 · United States
NIDCR NIH HHS · R01 DE016326-01A1 · United States
NIAID NIH HHS · R01 AI063031-02 · United States
NIAID NIH HHS · R01 AI063031-04 · United States
NIDCR NIH HHS · R01 DE016326-05 · United States
NIAID NIH HHS · U54 AI057157-075827 · United States
NIAID NIH HHS · R01-AI063031 · United States
NIAID NIH HHS · R01 AI063031-05 · United States
NIDCR NIH HHS · R01 DE016326-03 · United States
NIAID NIH HHS · R01 AI063031 · United States
NIDCR NIH HHS · R01-DE018281 · United States
NIAID NIH HHS · U54 AI057157-010006 · United States
NIAID NIH HHS · U54 AI057157-085827 · United States
NIAID NIH HHS · R01 AI063031-03 · United States
NIDCR NIH HHS · R01 DE016326-02 · United States
NIAID NIH HHS · U54-AI057157 · United States
NIDCR NIH HHS · R01 DE016326 · United States
NIDCR NIH HHS · R01 DE016326-04 · United States
NIAID NIH HHS · U54 AI057157-06S10016 · United States
NIAID NIH HHS · U54 AI057157 · United States
External Links
PubMed source DOI: 10.1016/j.chom.2010.06.005 PMC Full Text View journal details
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