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PMID: 20847397 Published · ppublish English Comparative Study Journal Article Meta-Analysis Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.

Journal of Alzheimer's disease : JAD ·Vol. 22 ·No. 1 ·2010-00-00 ·Pages 247-55

Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P

Abstract

The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.

MeSH Terms
Age of Onset Aged Aged, 80 and over Alleles Alzheimer Disease/epidemiology,genetics Apolipoprotein E4/genetics,metabolism Calcium Channels/genetics,metabolism Case-Control Studies Female Humans Male Membrane Glycoproteins/genetics,metabolism Middle Aged Polymorphism, Genetic/genetics
Chemicals
Apolipoprotein E4 CALHM1 protein, human Calcium Channels Membrane Glycoproteins
Authors & Affiliations
75 authors, click to expand affiliations / ORCID
Lambert Jean-Charles
Unité INSERM 744, Institut Pasteur de Lille BP 245,1, rue du professeur Calmette, F59019Lille cedex, France. [email protected]
Sleegers Kristel
González-Pérez Antonio
Ingelsson Martin
Beecham Gary W
Hiltunen Mikko
Combarros Onofre
Bullido Maria J
Brouwers Nathalie
Bettens Karolien
Berr Claudine
Pasquier Florence
Richard Florence
Dekosky Steven T
Hannequin Didier
Haines Jonathan L
Tognoni Gloria
Fiévet Nathalie
Dartigues Jean-François
Tzourio Christophe
Engelborghs Sebastiaan
Arosio Beatrice
Coto Elicer
De Deyn Peter
Del Zompo Maria
Mateo Ignacio
Boada Merce
Antunez Carmen
Lopez-Arrieta Jesus
Epelbaum Jacques
Schjeide Brit-Maren Michaud
Frank-Garcia Ana
Giedraitis Vilmentas
Helisalmi Seppo
Porcellini Elisa
Pilotto Alberto
Forti Paola
Ferri Raffaele
Delepine Marc
Zelenika Diana
Lathrop Mark
Scarpini Elio
Siciliano Gabriele
Solfrizzi Vincenzo
Sorbi Sandro
Spalletta Gianfranco
Ravaglia Giovanni
Valdivieso Fernando
Vepsäläinen Saila
Alvarez Victoria
Bosco Paolo
Mancuso Michelangelo
Panza Francesco
Nacmias Benedetta
Bossù Paola
Hanon Olivier
Piccardi Paola
Annoni Giorgio
Mann David
Marambaud Philippe
Seripa Davide
Galimberti Daniela
Tanzi Rudolph E
Bertram Lars
Lendon Corinne
Lannfelt Lars
Licastro Federico
Campion Dominique
Pericak-Vance Margaret A
Soininen Hilkka
Van Broeckhoven Christine
Alpérovitch Annick
Ruiz Agustin
Kamboh M Ilyas
Amouyel Philippe
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Article Info
Journal
Journal of Alzheimer's disease : JAD
Abbr.
J Alzheimers Dis
ISSN
1875-8908
DOI
10.3233/JAD-2010-100933
Email
[email protected]
Published
2010-00-00
Pages
247-55
Language
English
Region
Netherlands
NLM ID
9814863
PMCID
PMC2964875
Subset
IM
Grants
NIA NIH HHS · AG19757 · United States
NINDS NIH HHS · R01 NS031153 · United States
NIA NIH HHS · R01 AG030653-02 · United States
NIA NIH HHS · AG030653 · United States
NIA NIH HHS · P50 AG005133 · United States
NINDS NIH HHS · NS31153 · United States
NIA NIH HHS · R01 AG030653 · United States
NIA NIH HHS · AG20135 · United States
NIA NIH HHS · R01 AG020135 · United States
NIA NIH HHS · R01 AG019757 · United States
NIA NIH HHS · AG005133 · United States
NIA NIH HHS · P50 AG005133-219007 · United States
External Links
PubMed source DOI: 10.3233/JAD-2010-100933 PMC Full Text View journal details
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