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PMID: 20920752 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.

Advances in genetics ·Vol. 70 ·2010-00-00 ·Pages 277-308

Kalari S, Pfeifer GP

Abstract

Human cancer genomes are characterized by widespread aberrations in DNA methylation patterns including DNA hypomethylation of mostly repetitive sequences and hypermethylation of numerous CpG islands. The analysis of DNA methylation patterns in cancer has progressed from single gene studies examining potentially important candidate genes to a more global analysis where all or almost all promoter and CpG island sequences can be analyzed. We provide a brief overview of these genome-scale methylation-profiling techniques, summarize some of the information that has been obtained with these approaches, and discuss what we have learned about the specificity of methylation aberrations in cancer at a genome-wide level. The challenge is now to identify those methylation changes that are thought to be crucial for the processes of tumor initiation, tumor progression, or metastasis and distinguish these from methylation changes that are merely passenger events that accompany the transformation process but have no effect per se on the process of carcinogenesis.

MeSH Terms
Cell Transformation, Neoplastic/genetics Chromatin/metabolism CpG Islands DNA Methylation Epigenesis, Genetic Female Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Genomic Instability Humans Male Neoplasms/genetics Polycomb-Group Proteins Repressor Proteins/metabolism Signal Transduction Wnt Proteins/metabolism
Chemicals
Chromatin Polycomb-Group Proteins Repressor Proteins Wnt Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kalari Satish
Department of Cancer Biology, Beckman Research Institute of the Cityof Hope, Duarte, CA, USA.
Pfeifer Gerd P
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Article Info
Journal
Advances in genetics
Abbr.
Adv Genet
ISSN
0065-2660
DOI
10.1016/B978-0-12-380866-0.60010-1
Published
2010-00-00
Pages
277-308
Language
English
Region
United States
NLM ID
0370421
PMCID
PMC2951285
Subset
IM
Grants
NCI NIH HHS · R01 CA084469 · United States
NCI NIH HHS · R01 CA084469-12 · United States
NCI NIH HHS · CA084469 · United States
External Links
PubMed source DOI: 10.1016/B978-0-12-380866-0.60010-1 PMC Full Text View journal details
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