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PMID: 20930268 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study.

Journal of Alzheimer's disease : JAD ·Vol. 23 ·No. 2 ·2011-00-00 ·Pages 249-55

Wilson RS, Barral S, Lee JH, Leurgans SE, Foroud TM, Sweet RA, Graff-Radford N, Bird TD, Mayeux R, Bennett DA

Abstract

The study aim was to estimate the genetic contribution to individual differences in different forms of memory in a large family-based group of older adults. As part of the Late Onset Alzheimer's Disease Family Study, 899 persons (277 with Alzheimer's disease, 622 unaffected) from 325 families completed a battery of memory tests from which previously established composite measures of episodic memory, semantic memory, and working memory were derived. Heritability in these measures was estimated using the maximum likelihood variance component method, controlling for age, gender, and education. In analyses of unaffected family members, the adjusted heritability estimates were 0.62 for episodic memory, 0.49 for semantic memory, and 0.72 for working memory, where a heritability estimate of 1 indicates that genetic factors explain all of the phenotypic variance and a heritability of 0 indicates that genetic factors explain none. Adjustment for APOE genotype had little effect on these estimates. When analyses included affected and unaffected family members, adjusted heritability estimates were lower (0.47 for episodic memory, 0.32 for semantic memory, 0.42 for working memory). Adjusting for APOE slightly reduced the estimate for episodic memory (0.40) but had no effect on the remaining estimates. The results indicate that memory functions are under strong genetic influence in older persons with and without AD, and are only partly attributable to APOE. This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD.

MeSH Terms
Alleles Alzheimer Disease/genetics,psychology Apolipoproteins E/genetics Endophenotypes Female Genetic Predisposition to Disease Genotype Humans Male Memory/physiology Neuropsychological Tests
Chemicals
Apolipoproteins E
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Wilson Robert S
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA. [email protected]
Barral Sandra
Lee Joseph H
Leurgans Sue E
Foroud Tatiana M
Sweet Robert A
Graff-Radford Neill
Bird Thomas D
Mayeux Richard
Bennett David A
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Article Info
Journal
Journal of Alzheimer's disease : JAD
Abbr.
J Alzheimers Dis
ISSN
1875-8908
DOI
10.3233/JAD-2010-101515
Email
[email protected]
Published
2011-00-00
Pages
249-55
Language
English
Region
Netherlands
NLM ID
9814863
PMCID
PMC3130303
Subset
IM
Grants
NIA NIH HHS · P30 AG013854 · United States
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NIA NIH HHS · P30 AG028383 · United States
NIA NIH HHS · P30 AG008017-12S1 · United States
NIA NIH HHS · P30 AG010124-11 · United States
NIA NIH HHS · P30 AG010161-18 · United States
NIA NIH HHS · P30 AG028377-03 · United States
NIA NIH HHS · P50 AG016574-06S3 · United States
NIA NIH HHS · P50 AG016574-04 · United States
NIA NIH HHS · P30 AG010133-20 · United States
NIA NIH HHS · P50 AG005136-16 · United States
NIA NIH HHS · P50 AG016574-04S1 · United States
NIA NIH HHS · P50 AG008702-12 · United States
NIA NIH HHS · P30 AG010124-16 · United States
NIA NIH HHS · P50 AG005142-23 · United States
NIA NIH HHS · R01 AG027224-01A2 · United States
NIA NIH HHS · P50 AG005136-20S1 · United States
NIA NIH HHS · P30 AG010133-12S1 · United States
NIA NIH HHS · P50 AG005136-21S1 · United States
NIA NIH HHS · P30 AG013854-04S3 · United States
NIA NIH HHS · P50 AG005136-21S2 · United States
NIA NIH HHS · P50 AG016582-09S1 · United States
NIA NIH HHS · R01 AG024871-03 · United States
NIA NIH HHS · P30AG028377 · United States
NIA NIH HHS · P30 AG028377-02 · United States
NIA NIH HHS · P30 AG013854-15 · United States
NIA NIH HHS · U24 AG026395-05 · United States
NIA NIH HHS · P50 AG016582-10S1 · United States
NIA NIH HHS · R01 AG017917-05 · United States
NIA NIH HHS · P30 AG008017-15 · United States
NIA NIH HHS · P30 AG013846-06 · United States
NIA NIH HHS · P30 AG008017-15S2 · United States
NIA NIH HHS · P30 AG008017-10S2 · United States
NIA NIH HHS · P50 AG005681-22 · United States
NIA NIH HHS · P50 AG005681-22S2 · United States
NIA NIH HHS · P50 AG005138-26 · United States
NIA NIH HHS · P50 AG008702-15 · United States
NIA NIH HHS · P50 AG005136-26 · United States
NIA NIH HHS · R01 AG024871-02 · United States
NIA NIH HHS · P50 AG008702-14S2 · United States
NIA NIH HHS · P50AG05138 · United States
NIA NIH HHS · P30 AG013846-09S2 · United States
NIA NIH HHS · P30 AG008017-21 · United States
NIA NIH HHS · P50 AG008702-10S3 · United States
External Links
PubMed source DOI: 10.3233/JAD-2010-101515 PMC Full Text View journal details
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