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PMID: 20937126 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Molecular mechanisms of tiling and self-avoidance in neural development.

Molecular brain ·Vol. 3 ·No. 1 ·2010-10-11 ·Pages 28

Cameron S, Rao Y

Abstract

Recent studies have begun to unravel the molecular basis of tiling and self-avoidance, two important cellular mechanisms that shape neuronal circuitry during development in both invertebrates and vertebrates. Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance. By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner. These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.

MeSH Terms
Activins/metabolism Animals Axons/metabolism Cell Communication Humans Nervous System/cytology,growth & development Neurons/metabolism Signal Transduction
Chemicals
Activins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cameron Scott
McGill Centre for Research in Neuroscience, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
Rao Yong
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Article Info
Journal
Molecular brain
Abbr.
Mol Brain
ISSN
1756-6606
DOI
10.1186/1756-6606-3-28
Published
2010-10-11
Epub
2010-00-11
Pages
28
Language
English
Region
England
NLM ID
101468876
PMCID
PMC2959082
Subset
IM
Grants
Canadian Institutes of Health Research · MOP-14688 · Canada
External Links
PubMed source DOI: 10.1186/1756-6606-3-28 PMC Full Text View journal details
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