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PMID: 20966254 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.

Science (New York, N.Y.) ·Vol. 330 ·No. 6003 ·2010-10-22 ·Pages 514-517

Neafsey DE, Lawniczak MKN, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N, Costantini C, Johnson C, Wiegand RC, Collins FH, Lander ES, Wirth DF, Kafatos FC, Besansky NJ, Christophides GK, Muskavitch MAT

Abstract

Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.

MeSH Terms
Animals Anopheles/genetics Female Gene Flow Genes, Insect Genotype Insect Vectors/genetics Malaria Polymorphism, Single Nucleotide/genetics
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Neafsey D E
Broad Institute, Cambridge, MA 02142, USA.
Lawniczak M K N
Imperial College London, London SW7 2AZ, UK.
Park D J
Broad Institute, Cambridge, MA 02142, USA.
Redmond S N
Imperial College London, London SW7 2AZ, UK.
Coulibaly M B
Malaria Research and Training Center, Bamako, Mali.
Traoré S F
Malaria Research and Training Center, Bamako, Mali.
Sagnon N
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso.
Costantini C
Institut de Recherche pour le Développement, Unité de Recherche R016, Montpellier, France. | Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Yaounde, Cameroon.
Johnson C
Broad Institute, Cambridge, MA 02142, USA.
Wiegand R C
Broad Institute, Cambridge, MA 02142, USA.
Collins F H
University of Notre Dame, Notre Dame, IN 46556, USA.
Lander E S
Broad Institute, Cambridge, MA 02142, USA.
Wirth D F
Broad Institute, Cambridge, MA 02142, USA. | Harvard School of Public Health, Boston, MA 02115, USA.
Kafatos F C
Imperial College London, London SW7 2AZ, UK.
Besansky N J
University of Notre Dame, Notre Dame, IN 46556, USA.
Christophides G K
Imperial College London, London SW7 2AZ, UK.
Muskavitch M A T
Broad Institute, Cambridge, MA 02142, USA. | Harvard School of Public Health, Boston, MA 02115, USA. | Boston College, Chestnut Hill, MA 02467, USA.
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1193036
Published
2010-10-22
Pages
514-517
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC4811326
Subset
IM
Grants
Wellcome Trust · 077229 · United Kingdom
NHGRI NIH HHS · U54 HG003067 · United States
Biotechnology and Biological Sciences Research Council · BB/E002641/1 · United Kingdom
Wellcome Trust · 077229/Z/05/Z · United Kingdom
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1126/science.1193036 PMC Full Text View journal details
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