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PMID: 21030644 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Molecular signals of epigenetic states.

Science (New York, N.Y.) ·Vol. 330 ·No. 6004 ·2010-10-29 ·Pages 612-6

Bonasio R, Tu S, Reinberg D

Abstract

Epigenetic signals are responsible for the establishment, maintenance, and reversal of metastable transcriptional states that are fundamental for the cell's ability to "remember" past events, such as changes in the external environment or developmental cues. Complex epigenetic states are orchestrated by several converging and reinforcing signals, including transcription factors, noncoding RNAs, DNA methylation, and histone modifications. Although all of these pathways modulate transcription from chromatin in vivo, the mechanisms by which epigenetic information is transmitted through cell division remain unclear. Because epigenetic states are metastable and change in response to the appropriate signals, a deeper understanding of their molecular framework will allow us to tackle the dysregulation of epigenetics in disease.

MeSH Terms
Animals Cell Division Chromatin/chemistry,genetics,metabolism DNA Methylation Epigenesis, Genetic Histones/metabolism Humans Protein Processing, Post-Translational RNA, Untranslated/genetics,metabolism Transcription Factors/metabolism Transcription, Genetic
Chemicals
Chromatin Histones RNA, Untranslated Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bonasio Roberto
Howard Hughes Medical Institute and Department of Biochemistry, School of Medicine, New York University, New York, NY 10016, USA.
Tu Shengjiang
Reinberg Danny
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1191078
Published
2010-10-29
Pages
612-6
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3772643
Subset
IM
Grants
NIGMS NIH HHS · R01 GM037120 · United States
NIGMS NIH HHS · GM064844 · United States
NIGMS NIH HHS · GM037120 · United States
NIGMS NIH HHS · R37 GM037120 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM064844 · United States
External Links
PubMed source DOI: 10.1126/science.1191078 PMC Full Text View journal details
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