Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.
Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration. Here we show that the rearrangement of the bcl-2 gene occurs in a significant fraction (approximately of 10%) of B cell CLL. In all cases analyzed, breakpoints on chromosome 18 clustered at the 5' flanking region of the bcl-2 gene, and no rearrangements were found at the major or minor breakpoint clustering region (3' region of bcl-2 gene) typical of the t(14;18) chromosome translocation. All of the rearranged bcl-2 genes were juxtaposed with the Ig lambda or K genes in a head-to-head configuration. These results imply that the bcl-2 gene is preferentially linked to the IgL genes in CLL and could function in leukemogenesis.
16 references, click to expand
-
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.Proc Natl Acad Sci U S A. 1985 Nov;82(21):7439-43 PMID: 2865728
-
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.Science. 1985 Sep 27;229(4720):1390-3 PMID: 3929382
-
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.Proc Natl Acad Sci U S A. 1986 Jul;83(14):5214-8 PMID: 3523487
-
Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer.N Engl J Med. 1987 Jan 8;316(2):79-84 PMID: 3537802
-
DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene.Proc Natl Acad Sci U S A. 1987 Mar;84(5):1329-31 PMID: 3547408
-
Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas.N Engl J Med. 1987 Nov 5;317(19):1185-9 PMID: 3657890
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.Nature. 1988 Sep 29;335(6189):440-2 PMID: 3262202
-
bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.Cell. 1989 Apr 7;57(1):79-88 PMID: 2649247
-
Variant translocation of the bcl-2 gene to immunoglobulin lambda light chain gene in chronic lymphocytic leukemia.Proc Natl Acad Sci U S A. 1989 Apr;86(8):2771-4 PMID: 2704746
-
Juxtaposition of human bcl-2 and immunoglobulin lambda light chain gene in chronic lymphocytic leukemia is the result of a reciprocal chromosome translocation between chromosome 18 and 22.Oncogene. 1989 Sep;4(9):1073-5 PMID: 2506501
-
Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.Oncogene. 1989 Nov;4(11):1331-6 PMID: 2554236
-
Clustered arrangement of immunoglobulin lambda constant region genes in man.Nature. 1981 Dec 10;294(5841):536-40 PMID: 6273747
-
Evolution of human immunoglobulin kappa J region genes.J Biol Chem. 1982 Feb 10;257(3):1516-22 PMID: 6276389
-
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.Cell. 1985 Jul;41(3):899-906 PMID: 3924412
-
Involvement of the bcl-2 gene in human follicular lymphoma.Science. 1985 Jun 21;228(4706):1440-3 PMID: 3874430
-
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.J Exp Med. 1986 Jul 1;164(1):315-20 PMID: 3014037
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
