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PMID: 21078970 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 107 ·No. 49 ·2010-12-07 ·Pages 21199-204

Li Y, Huang Y, Bergelson J, Nordborg M, Borevitz JO

Abstract

Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain and Sweden. Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.

MeSH Terms
Acclimatization/genetics Arabidopsis/genetics Chromosome Mapping Flowers/genetics Genome-Wide Association Study Polymorphism, Single Nucleotide Quantitative Trait Loci Seasons Spain Sweden
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Li Yan
Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.
Huang Yu
Bergelson Joy
Nordborg Magnus
Borevitz Justin O
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1007431107
Published
2010-12-07
Epub
2010-00-15
Pages
21199-204
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3000268
Subset
IM
Grants
NIGMS NIH HHS · R01 GM073822 · United States
NIGMS NIH HHS · R01GM073822 · United States
External Links
PubMed source DOI: 10.1073/pnas.1007431107 PMC Full Text View journal details
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