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PMID: 21110998 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog.

Developmental and comparative immunology ·Vol. 35 ·No. 4 ·2011-04-00 ·Pages 461-8

Zhang Q, Zmasek CM, Cai X, Godzik A

Abstract

Toll/interleukin-1 receptor (TIR) domain-containing proteins play important roles in defense against pathogens in both animals and plants, connecting the immunity signaling pathways via a chain of specific protein-protein interactions. Among them is SARM, the only TIR domain-containing adaptor that can negatively regulate TLR signaling. By extensive phylogenetic analysis, we show here that SARM is closely related to bacterial proteins with TIR domains, suggesting that this family has a different evolutionary history from other animal TIR-containing adaptors, possibly emerging via a lateral gene transfer from bacteria to animals. We also show evidence of several similar, independent transfer events, none of which, however, survived in vertebrates. An evolutionary relationship between the animal SARM adaptor and bacterial proteins with TIR domains illustrates the possible role that bacterial TIR-containing proteins play in regulating eukaryotic immune responses and how this mechanism was possibly adapted by the eukaryotes themselves.

MeSH Terms
Animals Cytoskeletal Proteins/chemistry,genetics,immunology Evolution, Molecular Gene Transfer, Horizontal Host-Pathogen Interactions Humans Metagenomics Models, Molecular Phylogeny Protein Structure, Tertiary Receptors, Interleukin-1/chemistry,genetics,immunology Signal Transduction
Chemicals
Cytoskeletal Proteins Receptors, Interleukin-1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zhang Qing
Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Zmasek Christian M
Cai Xiaohui
Godzik Adam
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Article Info
Journal
Developmental and comparative immunology
Abbr.
Dev Comp Immunol
ISSN
1879-0089
DOI
10.1016/j.dci.2010.11.013
Published
2011-04-00
Epub
2010-00-24
Pages
461-8
Language
English
Region
United States
NLM ID
7708205
PMCID
PMC3085110
Subset
IM
Grants
NIGMS NIH HHS · P20 GM076221-01 · United States
NIGMS NIH HHS · P20 GM076221 · United States
NIGMS NIH HHS · GM076221 · United States
NIGMS NIH HHS · R01 GM087218 · United States
NIGMS NIH HHS · R01 GM087218-01 · United States
External Links
PubMed source DOI: 10.1016/j.dci.2010.11.013 PMC Full Text View journal details
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