Chromosome of the mature virion of simian virus 40 contains H1 histone.

Nucleic acids research ·Vol. 5 ·No. 8 ·1978-08-00 ·Pages 2847-60

Nedospasov SA, Bakayev VV, Georgiev GP

Abstract

In addition to free SV40 minichromosomes in the compact form, complete virions were obtained from the nuclear extract of productively infected cells. Capsid proteins VP1, VP2, and VP3, as well as histones, were observed on electrophoregrams of proteins prepared from virions. In contrast to the widely accepted view, histone H1 was found in virions in stoichiometric amounts with respect to other histones. The same is true for virions isolated by a conventional method. Free minichromosomes present in infected cells contain all histones and practically no viral proteins.

MeSH Terms

Chromatin/metabolism,ultrastructure Chromosomes/metabolism,ultrastructure DNA, Viral/metabolism Histones/metabolism Simian virus 40/metabolism,ultrastructure Viral Proteins/metabolism

Chemicals

Chromatin DNA, Viral Histones Viral Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Nedospasov S A

Bakayev V V

Georgiev G P

References (15)

15 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/5.8.2847

Published

1978-08-00

Pages

2847-60

Language

English

Region

England

NLM ID

0411011

PMCID

PMC342211

Subset

External Links

PubMed source DOI: 10.1093/nar/5.8.2847 PMC Full Text View journal details

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Chromosome of the mature virion of simian virus 40 contains H1 histone.

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