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PMID: 2117155 Published · ppublish English Journal Article Review

The role of eosinophils in asthma.

Lung ·Vol. 168 Suppl ·1990-00-00 ·Pages 5-17

Kroegel C

Abstract

During recent years it has become apparent that the eosinophil may represent a powerful effector cell in the pathogenesis of asthma, particularly in the late asthmatic response. It can be stimulated by a number of stimuli among which PAF appears to be one of the most effective. The eosinophil is a source for a variety of proinflammatory and toxic products with profound effect in the lungs and airways. These eosinophil products mimic some of the features of asthma and the strong association of the eosinophil with asthma has led to the suggestion that asthma would be better classified as "chronic desquamating eosinophilic bronchitis." Although the evidence known to date is persuasive many questions still remain unanswered and await further investigation. Future therapeutic approaches in asthma may aim at interrupting the mechanisms leading to eosinophil bronchial accumulation and activation.

MeSH Terms
Airway Resistance/physiology Asthma/physiopathology Bronchi/physiopathology Bronchoalveolar Lavage Fluid/cytology Eosinophils/physiology Humans Platelet Activating Factor/physiology
Chemicals
Platelet Activating Factor
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kroegel C
Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, United Kingdom.
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Article Info
Journal
Lung
Abbr.
Lung
ISSN
0341-2040
DOI
10.1007/BF02718107
Published
1990-00-00
Pages
5-17
Language
English
Region
United States
NLM ID
7701875
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02718107 View journal details
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