The reactive serine residue of epidermolytic toxin A.

The Biochemical journal ·Vol. 269 ·No. 2 ·1990-07-15 ·Pages 535-7

Bailey CJ, Smith TP

Abstract

Comparison of amino acid sequence data suggested that there may be a functional relationship between the staphylococcal epidermolytic toxins and V8 proteinase. The hypothesis was tested by treating epidermolytic toxin with di-isopropyl phosphorofluoridate, which bound specifically at serine-195, the homologue of the active-site serine residue of V8 proteinase.

MeSH Terms

Amino Acid Sequence Bacterial Toxins Binding Sites Chromatography, High Pressure Liquid Exfoliatins Isoflurophate Molecular Sequence Data Peptide Fragments Sequence Homology, Nucleic Acid Serine Serine Endopeptidases Staphylococcus aureus/metabolism Trypsin

Chemicals

Bacterial Toxins Exfoliatins Peptide Fragments Isoflurophate Serine Serine Endopeptidases glutamyl endopeptidase Trypsin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bailey C J

Department of Biochemistry, Trinity College, Dublin, Ireland.

Smith T P

References (17)

17 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2690535

Published

1990-07-15

Pages

535-7

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1131611

Subset

External Links

PubMed source DOI: 10.1042/bj2690535 PMC Full Text View journal details

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The reactive serine residue of epidermolytic toxin A.

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