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PMID: 21191176 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Substrate-specific regulation of ubiquitination by the anaphase-promoting complex.

Cell cycle (Georgetown, Tex.) ·Vol. 10 ·No. 1 ·2011-01-01 ·Pages 52-6

Song L, Rape M

Abstract

By orchestrating the sequential degradation of a large number of cell cycle regulators, the ubiquitin ligase anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The correct timing of APC/C-dependent substrate degradation, a critical feature of progression through mitosis, was long known to be controlled by mechanisms targeting the core APC/C-machinery. Recent experiments, however, have revealed an important contribution of substrate-specific regulation of the APC/C to achieve accurate cell division. In this perspective, we describe different mechanisms of substrate-specific APC/C-regulation and discuss their importance for cell division.

MeSH Terms
Anaphase-Promoting Complex-Cyclosome Animals Cell Division/physiology Humans Protein Binding/physiology Substrate Specificity/physiology Ubiquitin-Protein Ligase Complexes/physiology Ubiquitination/physiology
Chemicals
Ubiquitin-Protein Ligase Complexes Anaphase-Promoting Complex-Cyclosome
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Song Ling
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Rape Michael
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Article Info
Journal
Cell cycle (Georgetown, Tex.)
Abbr.
Cell Cycle
ISSN
1551-4005
DOI
10.4161/cc.10.1.14387
Published
2011-01-01
Epub
2011-00-01
Pages
52-6
Language
English
Region
United States
NLM ID
101137841
PMCID
PMC3048074
Subset
IM
External Links
PubMed source DOI: 10.4161/cc.10.1.14387 PMC Full Text View journal details
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