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PMID: 21282520 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Cardiovascular molecular imaging: focus on clinical translation.

Circulation ·Vol. 123 ·No. 4 ·2011-02-01 ·Pages 425-43

Chen IY, Wu JC

Abstract

暂无摘要

MeSH Terms
Animals Atherosclerosis/diagnosis Cardiovascular Diseases/diagnosis Female Heart Failure/diagnosis Humans Magnetic Resonance Imaging Mice Molecular Imaging/methods Myocardial Reperfusion Injury/diagnosis Myocardial Revascularization Stem Cell Transplantation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chen Ian Y
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5111, USA.
Wu Joseph C
References (156)
156 references, click to expand
  1. Serial noninvasive in vivo positron emission tomographic tracking of percutaneously intramyocardially injected autologous porcine mesenchymal stem cells modified for transgene reporter gene expression.
    Circ Cardiovasc Imaging. 2008 Sep;1(2):94-103 PMID: 19808526
  2. Results of the Predictors of Response to CRT (PROSPECT) trial.
    Circulation. 2008 May 20;117(20):2608-16 PMID: 18458170
  3. Myocardial homing and coronary endothelial function after autologous blood CD34+ progenitor cells intracoronary injection in the chronic phase of myocardial infarction.
    J Cardiovasc Pharmacol. 2009 Jun;53(6):480-5 PMID: 19433985
  4. Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction.
    Circ Cardiovasc Imaging. 2010 Jan;3(1):77-85 PMID: 19920031
  5. Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosis.
    JACC Cardiovasc Imaging. 2009 May;2(5):637-47 PMID: 19442953
  6. Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations.
    J Nucl Med. 2008 Jun;49(6):871-8 PMID: 18483100
  7. Molecular imaging in atherosclerosis, thrombosis, and vascular inflammation.
    Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):983-91 PMID: 19213945
  8. Molecular imaging in living subjects: seeing fundamental biological processes in a new light.
    Genes Dev. 2003 Mar 1;17(5):545-80 PMID: 12629038
  9. Molecular magnetic resonance imaging of deep vein thrombosis using a fibrin-targeted contrast agent: a feasibility study.
    Invest Radiol. 2009 Mar;44(3):146-50 PMID: 19151606
  10. Pilot trial on determinants of progenitor cell recruitment to the infarcted human myocardium.
    Circulation. 2008 Sep 30;118(14):1425-32 PMID: 18794392
  11. Glucose and glycogen utilisation in myocardial ischemia--changes in metabolism and consequences for the myocyte.
    Mol Cell Biochem. 1998 Mar;180(1-2):3-26 PMID: 9546626
  12. Molecular coronary MR imaging of human thrombi using EP-2104R, a fibrin-targeted contrast agent: experimental study in a swine model.
    Rofo. 2007 Nov;179(11):1166-73 PMID: 17948194
  13. 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques.
    Eur J Nucl Med Mol Imaging. 2006 Feb;33(2):117-26 PMID: 16220305
  14. Quantum dot imaging for embryonic stem cells.
    BMC Biotechnol. 2007 Oct 09;7:67 PMID: 17925032
  15. Imaging myocardial angiogenesis.
    Nat Rev Cardiol. 2009 Oct;6(10):648-58 PMID: 19736553
  16. Atherosclerosis: imaging techniques and the evolving role of nuclear medicine.
    J Nucl Med. 1997 Nov;38(11):1788-96 PMID: 9374357
  17. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.
    Circ Cardiovasc Imaging. 2009 Nov;2(6):460-7 PMID: 19920044
  18. Genetic enhancement of stem cell engraftment, survival, and efficacy.
    Circ Res. 2008 Jun 20;102(12):1471-82 PMID: 18566313
  19. In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging.
    Circulation. 2008 Jul 8;118(2):140-8 PMID: 18574049
  20. Delayed-enhancement cardiovascular magnetic resonance coronary artery wall imaging: comparison with multislice computed tomography and quantitative coronary angiography.
    J Am Coll Cardiol. 2007 Jul 31;50(5):441-7 PMID: 17662397
  21. Molecular imaging: antidote to cardiac stem cell controversy.
    J Am Coll Cardiol. 2008 Nov 11;52(20):1661-4 PMID: 18992657
  22. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes.
    Circulation. 2008 Jun 24;117(25):3206-15 PMID: 18541740
  23. (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials.
    J Am Coll Cardiol. 2007 Aug 28;50(9):892-6 PMID: 17719477
  24. Molecular imaging in heart failure.
    Curr Opin Biotechnol. 2007 Feb;18(1):65-72 PMID: 17204414
  25. Protein scaffold-based molecular probes for cancer molecular imaging.
    Amino Acids. 2011 Nov;41(5):1037-47 PMID: 20174842
  26. Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis.
    Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2103-9 PMID: 16825592
  27. Fusion of positron emission tomography and coronary computed tomographic angiography identifies fluorine 18 fluorodeoxyglucose uptake in the left main coronary artery soft plaque.
    J Nucl Cardiol. 2008 Nov-Dec;15(6):841-3 PMID: 18984461
  28. Systematic review: cardiac resynchronization in patients with symptomatic heart failure.
    Ann Intern Med. 2004 Sep 7;141(5):381-90 PMID: 15353430
  29. Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques.
    J Biomed Opt. 2010 Jan-Feb;15(1):011107 PMID: 20210433
  30. Molecular MRI of Atherosclerotic Plaque With Targeted Contrast Agents.
    Curr Cardiovasc Imaging Rep. 2009 Apr 1;2(2):87-94 PMID: 20019886
  31. Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction.
    J Am Coll Cardiol. 2008 Dec 9;52(24):2017-28 PMID: 19055994
  32. Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling.
    JACC Cardiovasc Imaging. 2009 Feb;2(2):187-98 PMID: 19356555
  33. Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis.
    Circulation. 2008 Jul 15;118(3):258-67 PMID: 18574047
  34. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.
    Circulation. 2008 Jan 22;117(3):379-87 PMID: 18158358
  35. The failing heart--an engine out of fuel.
    N Engl J Med. 2007 Mar 15;356(11):1140-51 PMID: 17360992
  36. Comparison of different adult stem cell types for treatment of myocardial ischemia.
    Circulation. 2008 Sep 30;118(14 Suppl):S121-9 PMID: 18824743
  37. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.
    Circulation. 2007 Jan 23;115(3):377-86 PMID: 17224478
  38. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study.
    J Am Coll Cardiol. 2010 May 18;55(20):2212-21 PMID: 20188504
  39. In vivo positive contrast IRON sequence and quantitative T(2)* measurement confirms inflammatory burden in a patient with asymptomatic carotid atheroma after USPIO-enhanced MR imaging.
    J Vasc Interv Radiol. 2008 Mar;19(3):446-8 PMID: 18295707
  40. Monitoring of bone marrow cell homing into the infarcted human myocardium.
    Circulation. 2005 May 3;111(17):2198-202 PMID: 15851598
  41. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
    N Engl J Med. 1982 Jul 22;307(4):205-11 PMID: 6283349
  42. In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.
    Circulation. 2006 Feb 21;113(7):1005-14 PMID: 16476845
  43. Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.
    Circulation. 2004 Mar 23;109(11):1415-20 PMID: 15007006
  44. Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction.
    J Nucl Med. 2006 Aug;47(8):1295-301 PMID: 16883008
  45. The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease.
    J Am Coll Cardiol. 2009 Jun 2;53(22):2039-50 PMID: 19477353
  46. A conceptual paradox of MIBG uptake in heart failure: retention with incontinence!
    J Nucl Cardiol. 2003 Nov-Dec;10(6):700-4 PMID: 14668785
  47. Phase I clinical evaluation of a new iron oxide MR contrast agent.
    J Magn Reson Imaging. 1994 May-Jun;4(3):301-7 PMID: 8061425
  48. 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons.
    FASEB J. 2007 Jun;21(8):1647-54 PMID: 17284484
  49. Biomarkers in heart failure.
    N Engl J Med. 2008 May 15;358(20):2148-59 PMID: 18480207
  50. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.
    Circulation. 2006 Oct 3;114(14):1504-11 PMID: 17000904
  51. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.
    Circ Res. 2007 Apr 27;100(8):1218-25 PMID: 17379832
  52. Heart disease and stroke statistics--2010 update: a report from the American Heart Association.
    Circulation. 2010 Feb 23;121(7):e46-e215 PMID: 20019324
  53. Prospects for personalized cardiovascular medicine: the impact of genomics.
    J Am Coll Cardiol. 2005 Nov 1;46(9):1615-27 PMID: 16256859
  54. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI.
    Stroke. 2004 Jul;35(7):1631-5 PMID: 15166394
  55. Radionuclide imaging: a molecular key to the atherosclerotic plaque.
    J Am Coll Cardiol. 2008 Jul 1;52(1):1-12 PMID: 18582628
  56. Visualisation of cell death in vivo in patients with acute myocardial infarction.
    Lancet. 2000 Jul 15;356(9225):209-12 PMID: 10963199
  57. Pathology of the unstable plaque.
    Prog Cardiovasc Dis. 2002 Mar-Apr;44(5):349-56 PMID: 12024333
  58. One-day kinetics of myocardial engraftment after intracoronary injection of bone marrow mononuclear cells in patients with acute and chronic myocardial infarction.
    Heart. 2007 Jul;93(7):837-41 PMID: 17309910
  59. Thrombus imaging with fibrin-specific gadolinium-based MR contrast agent EP-2104R: results of a phase II clinical study of feasibility.
    Invest Radiol. 2009 Nov;44(11):697-704 PMID: 19809344
  60. Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography.
    J Am Coll Cardiol. 2008 Nov 11;52(20):1652-60 PMID: 18992656
  61. Cardiac resynchronization therapy homogenizes myocardial glucose metabolism and perfusion in dilated cardiomyopathy and left bundle branch block.
    J Am Coll Cardiol. 2003 May 7;41(9):1523-8 PMID: 12742293
  62. Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy.
    Gene Ther. 2010 Jul;17(7):827-38 PMID: 20237511
  63. Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography.
    J Nucl Cardiol. 2005 May-Jun;12(3):294-301 PMID: 15944534
  64. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation.
    J Nucl Med. 2009 Apr;50(4):563-8 PMID: 19289431
  65. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis.
    Arch Intern Med. 2007 May 28;167(10):989-97 PMID: 17533201
  66. Fluorescence molecular imaging.
    Annu Rev Biomed Eng. 2006;8:1-33 PMID: 16834550
  67. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis.
    N Engl J Med. 2004 Apr 1;350(14):1472-3 PMID: 15070807
  68. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging.
    Circulation. 2003 May 20;107(19):2453-8 PMID: 12719280
  69. Radiolabeled arginine-glycine-aspartic acid peptides to image angiogenesis in swine model of hibernating myocardium.
    JACC Cardiovasc Imaging. 2008 Jul;1(4):500-10 PMID: 19198663
  70. Noninvasive imaging of angiotensin receptors after myocardial infarction.
    JACC Cardiovasc Imaging. 2008 May;1(3):354-62 PMID: 19356449
  71. In vivo molecular imaging of angiogenesis, targeting alphavbeta3 integrin expression, in a patient after acute myocardial infarction.
    Eur Heart J. 2008 Sep;29(18):2201 PMID: 18375397
  72. In vivo magnetic resonance imaging of coronary thrombosis using a fibrin-binding molecular magnetic resonance contrast agent.
    Circulation. 2004 Sep 14;110(11):1463-6 PMID: 15238457
  73. Red-shifted Renilla reniformis luciferase variants for imaging in living subjects.
    Nat Methods. 2007 Aug;4(8):641-3 PMID: 17618292
  74. MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients.
    Eur Radiol. 2008 Sep;18(9):1995-2005 PMID: 18425519
  75. Imaging in the era of molecular oncology.
    Nature. 2008 Apr 3;452(7187):580-9 PMID: 18385732
  76. Reverse perfusion-metabolism mismatch predicts good prognosis in patients undergoing cardiac resynchronization therapy: a pilot study.
    Circ J. 2007 Jan;71(1):126-31 PMID: 17186990
  77. Novel minicircle vector for gene therapy in murine myocardial infarction.
    Circulation. 2009 Sep 15;120(11 Suppl):S230-7 PMID: 19752373
  78. Multimodality cardiovascular molecular imaging, part I.
    Circ Cardiovasc Imaging. 2008 Nov;1(3):244-56 PMID: 19808549
  79. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography.
    J Am Coll Cardiol. 2006 Nov 7;48(9):1825-31 PMID: 17084257
  80. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.
    Circulation. 2006 Jul 4;114(1):55-62 PMID: 16801460
  81. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
    Nat Biotechnol. 2005 Nov;23(11):1418-23 PMID: 16244656
  82. Site-specific chromosomal integration mediated by phiC31 integrase.
    Methods Mol Biol. 2008;435:165-73 PMID: 18370075
  83. Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects.
    Stem Cells. 2008 Apr;26(4):864-73 PMID: 18218820
  84. Stem-cell therapy for cardiac disease.
    Nature. 2008 Feb 21;451(7181):937-42 PMID: 18288183
  85. Imaging survival and function of transplanted cardiac resident stem cells.
    J Am Coll Cardiol. 2009 Apr 7;53(14):1229-40 PMID: 19341866
  86. A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
    Arterioscler Thromb. 1992 Jan;12(1):120-34 PMID: 1731855
  87. Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium.
    Stem Cells. 2007 Oct;25(10):2677-84 PMID: 17628019
  88. Relationship of thrombus healing to underlying plaque morphology in sudden coronary death.
    J Am Coll Cardiol. 2010 Jan 12;55(2):122-32 PMID: 19818571
  89. Ultrasonic characterization of the nonlinear properties of contrast microbubbles.
    Ultrasound Med Biol. 2000 Jan;26(1):93-104 PMID: 10687797
  90. Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography.
    Circulation. 2003 Sep 16;108(11):1302-5 PMID: 12963637
  91. Cardiac iodine-123 metaiodobenzylguanidine imaging predicts sudden cardiac death independently of left ventricular ejection fraction in patients with chronic heart failure and left ventricular systolic dysfunction: results from a comparative study with signal-averaged electrocardiogram, heart rate variability, and QT dispersion.
    J Am Coll Cardiol. 2009 Feb 3;53(5):426-35 PMID: 19179201
  92. Prognostic value of myocardial 123I-metaiodobenzylguanidine (MIBG) parameters in patients with heart failure: a systematic review.
    Eur Heart J. 2008 May;29(9):1147-59 PMID: 18349024
  93. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo.
    Circulation. 2007 Mar 20;115(11):1384-91 PMID: 17339546
  94. Molecular imaging of innate immune cell function in transplant rejection.
    Circulation. 2009 Apr 14;119(14):1925-32 PMID: 19332470
  95. Basic acoustic properties of microbubbles.
    Echocardiography. 2002 Apr;19(3):229-40 PMID: 12022933
  96. Molecular magnetic resonance imaging of atrial clots in a swine model.
    Circulation. 2005 Jul 19;112(3):396-9 PMID: 16009790
  97. Magnetic resonance molecular imaging of thrombosis in an arachidonic acid mouse model using an activated platelet targeted probe.
    Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):403-10 PMID: 20139362
  98. Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.
    J Am Chem Soc. 2009 Oct 28;131(42):15522-7 PMID: 19795893
  99. Molecular Imaging of Myocardial Injury: A Magnetofluorescent Approach.
    Curr Cardiovasc Imaging Rep. 2009 Feb 1;2(1):33-39 PMID: 20090858
  100. Radionuclide noninvasive evaluation of heart failure beyond left ventricular function assessment.
    J Nucl Cardiol. 2009 Mar-Apr;16(2):304-15 PMID: 19247733
  101. Significance of one-bead-one-compound combinational chemistry.
    Nat Chem Biol. 2006 Jul;2(7):351-2 PMID: 16783336
  102. Multimodality imaging: beyond PET/CT and SPECT/CT.
    Semin Nucl Med. 2009 Sep;39(5):348-53 PMID: 19646559
  103. Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VI.
    PLoS One. 2009;4(5):e5585 PMID: 19440310
  104. Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.
    Transplantation. 2009 Mar 15;87(5):642-52 PMID: 19295307
  105. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression.
    Circulation. 2005 Jun 21;111(24):3248-54 PMID: 15956135
  106. Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering.
    Phys Med Biol. 2009 Mar 21;54(6):R27-57 PMID: 19229096
  107. Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output.
    Protein Eng Des Sel. 2006 Sep;19(9):391-400 PMID: 16857694
  108. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.
    Circulation. 2002 Jun 11;105(23):2708-11 PMID: 12057982
  109. Evaluation of metaiodobenzylguanidine uptake by the norepinephrine, dopamine and serotonin transporters.
    J Nucl Med. 1993 Jul;34(7):1140-6 PMID: 8315492
  110. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients.
    J Am Coll Cardiol. 2006 Nov 7;48(9):1818-24 PMID: 17084256
  111. Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.
    Circulation. 2008 Oct 28;118(18):1802-9 PMID: 18852366
  112. Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.
    Circulation. 2007 Sep 11;116(11 Suppl):I46-54 PMID: 17846325
  113. Inflammation, atherosclerosis, and coronary artery disease.
    N Engl J Med. 2005 Apr 21;352(16):1685-95 PMID: 15843671
  114. Autologous mononuclear bone marrow cells during reparative regeneratrion after acute myocardial infarction.
    Bull Exp Biol Med. 2005 Nov;140(5):640-3 PMID: 16758644
  115. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials.
    J Am Coll Cardiol. 2007 Oct 30;50(18):1761-7 PMID: 17964040
  116. Intracoronary infusion of CD133+ and CD133-CD34+ selected autologous bone marrow progenitor cells in patients with chronic ischemic cardiomyopathy: cell isolation, adherence to the infarcted area, and body distribution.
    Stem Cells. 2006 Oct;24(10):2279-83 PMID: 16794269
  117. Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure.
    J Nucl Med. 1992 Apr;33(4):471-7 PMID: 1552326
  118. Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods.
    Stroke. 2009 Jan;40(1):86-93 PMID: 18927453
  119. Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.
    Eur Heart J. 2008 Feb;29(4):445-54 PMID: 18276618
  120. Effects of cell number on teratoma formation by human embryonic stem cells.
    Cell Cycle. 2009 Aug 15;8(16):2608-12 PMID: 19597339
  121. PET with FDG-labeled leukocytes versus scintigraphy with 111In-oxine-labeled leukocytes for detection of infection.
    Radiology. 2006 Mar;238(3):978-87 PMID: 16505395
  122. Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias.
    N Engl J Med. 1991 Aug 29;325(9):618-24 PMID: 1861695
  123. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography.
    N Engl J Med. 1986 Apr 3;314(14):884-8 PMID: 3485252
  124. Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells.
    Proteomics. 2006 Dec;6(23):6234-49 PMID: 17080479
  125. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography.
    Nat Med. 2007 May;13(5):636-41 PMID: 17417649
  126. Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death.
    Circulation. 1996 Apr 1;93(7):1354-63 PMID: 8641024
  127. Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function.
    J Nucl Med. 1987 Oct;28(10):1620-4 PMID: 3655914
  128. Regeneration next: toward heart stem cell therapeutics.
    Cell Stem Cell. 2009 Oct 2;5(4):364-77 PMID: 19796617
  129. Nuclear magnetic resonance technology for medical studies.
    Science. 1984 Oct 19;226(4672):288-98 PMID: 6385252
  130. Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.
    Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12991-6 PMID: 18728188
  131. Comparison of imaging techniques for tracking cardiac stem cell therapy.
    J Nucl Med. 2007 Dec;48(12):1916-9 PMID: 18056330
  132. A human-derived reporter gene for noninvasive imaging in humans: mitochondrial thymidine kinase type 2.
    J Nucl Med. 2007 May;48(5):819-26 PMID: 17468435
  133. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.
    JACC Cardiovasc Imaging. 2009 Oct;2(10):1213-22 PMID: 19833312
  134. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.
    Circ Cardiovasc Imaging. 2009 Nov;2(6):468-75 PMID: 19920045
  135. Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles.
    Magn Reson Med. 2009 Apr;61(4):970-4 PMID: 19189296
  136. Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo.
    J Biomed Opt. 2005 Jul-Aug;10(4):41210 PMID: 16178634
  137. Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapy.
    Cardiovasc Res. 2009 Nov 1;84(2):190-200 PMID: 19628466
  138. Molecular imaging with targeted contrast ultrasound.
    Curr Opin Biotechnol. 2007 Feb;18(1):11-6 PMID: 17241779
  139. Myocardial homing of nonmobilized peripheral-blood CD34+ cells after intracoronary injection.
    Stem Cells. 2006 Feb;24(2):333-6 PMID: 16223854
  140. Clinical potential of quantum dots.
    J Biomed Biotechnol. 2007;2007(10):76087 PMID: 18317518
  141. Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.
    Circulation. 2009 Aug 18;120(7):592-9 PMID: 19652086
  142. Simultaneous PET-MRI: a new approach for functional and morphological imaging.
    Nat Med. 2008 Apr;14(4):459-65 PMID: 18376410
  143. Cardiac sympathetic nerve function in congestive heart failure.
    Circulation. 1996 May 1;93(9):1667-76 PMID: 8653872
  144. Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI.
    Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):961-6 PMID: 17215360
  145. (18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.
    J Nucl Med. 2004 Jul;45(7):1245-50 PMID: 15235073
  146. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling.
    Circulation. 2005 Nov 15;112(20):3157-67 PMID: 16275862
  147. An ApoA-I mimetic peptide high-density-lipoprotein-based MRI contrast agent for atherosclerotic plaque composition detection.
    Small. 2008 Sep;4(9):1437-44 PMID: 18712752
  148. The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography.
    Circ Res. 1989 Aug;65(2):458-67 PMID: 2752551
  149. Multimodality cardiovascular molecular imaging, Part II.
    Circ Cardiovasc Imaging. 2009 Jan;2(1):56-70 PMID: 19808565
  150. Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation.
    Mol Imaging Biol. 2009 May-Jun;11(3):178-87 PMID: 19034584
  151. Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.
    Nat Chem Biol. 2006 Jul;2(7):381-9 PMID: 16767086
  152. Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter.
    Tissue Eng Part C Methods. 2009 Dec;15(4):739-47 PMID: 19290800
  153. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.
    Circulation. 1995 Sep 15;92(6):1565-9 PMID: 7664441
  154. Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology.
    J Am Coll Cardiol. 2006 Jun 20;47(12):2405-12 PMID: 16781367
  155. Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.
    Nat Clin Pract Oncol. 2009 Jan;6(1):53-8 PMID: 19015650
  156. Predicting the need for an implantable cardioverter defibrillator using cardiac metaiodobenzylguanidine activity together with plasma natriuretic peptide concentration or left ventricular function.
    J Nucl Med. 2008 Feb;49(2):225-33 PMID: 18199625
Article Info
Journal
Circulation
Abbr.
Circulation
ISSN
1524-4539
Published
2011-02-01
Pages
425-43
Language
English
Region
United States
NLM ID
0147763
PMCID
PMC3073678
Subset
IM
Grants
NHLBI NIH HHS · R01 HL093172-02 · United States
NIBIB NIH HHS · R01 EB009689 · United States
NHLBI NIH HHS · R01 HL093172 · United States
NHLBI NIH HHS · HL093172 · United States
NIBIB NIH HHS · R01 EB009689-02 · United States
NIBIB NIH HHS · EB009689 · United States
NHLBI NIH HHS · RC1 HL099117-02 · United States
NHLBI NIH HHS · RC1 HL099117 · United States
NHLBI NIH HHS · HL099117 · United States
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