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PMID: 21297633 Published · ppublish English Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Nature genetics ·Vol. 43 ·No. 3 ·2011-03-00 ·Pages 246-52

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD

Abstract

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

MeSH Terms
Colitis, Ulcerative/genetics Crohn Disease/genetics Genome-Wide Association Study Humans Risk
Authors & Affiliations
113 authors, click to expand affiliations / ORCID
Anderson Carl A
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Boucher Gabrielle
Lees Charlie W
Franke Andre
D'Amato Mauro
Taylor Kent D
Lee James C
Goyette Philippe
Imielinski Marcin
Latiano Anna
Lagacé Caroline
Scott Regan
Amininejad Leila
Bumpstead Suzannah
Baidoo Leonard
Baldassano Robert N
Barclay Murray
Bayless Theodore M
Brand Stephan
Büning Carsten
Colombel Jean-Frédéric
Denson Lee A
De Vos Martine
Dubinsky Marla
Edwards Cathryn
Ellinghaus David
Fehrmann Rudolf S N
Floyd James A B
Florin Timothy
Franchimont Denis
Franke Lude
Georges Michel
Glas Jürgen
Glazer Nicole L
Guthery Stephen L
Haritunians Talin
Hayward Nicholas K
Hugot Jean-Pierre
Jobin Gilles
Laukens Debby
Lawrance Ian
Lémann Marc
Levine Arie
Libioulle Cecile
Louis Edouard
McGovern Dermot P
Milla Monica
Montgomery Grant W
Morley Katherine I
Mowat Craig
Ng Aylwin
Newman William
Ophoff Roel A
Papi Laura
Palmieri Orazio
Peyrin-Biroulet Laurent
Panés Julián
Phillips Anne
Prescott Natalie J
Proctor Deborah D
Roberts Rebecca
Russell Richard
Rutgeerts Paul
Sanderson Jeremy
Sans Miquel
Schumm Philip
Seibold Frank
Sharma Yashoda
Simms Lisa A
Seielstad Mark
Steinhart A Hillary
Targan Stephan R
van den Berg Leonard H
Vatn Morten
Verspaget Hein
Walters Thomas
Wijmenga Cisca
Wilson David C
Westra Harm-Jan
Xavier Ramnik J
Zhao Zhen Z
Ponsioen Cyriel Y
Andersen Vibeke
Torkvist Leif
Gazouli Maria
Anagnou Nicholas P
Karlsen Tom H
Kupcinskas Limas
Sventoraityte Jurgita
Mansfield John C
Kugathasan Subra
Silverberg Mark S
Halfvarson Jonas
Rotter Jerome I
Mathew Christopher G
Griffiths Anne M
Gearry Richard
Ahmad Tariq
Brant Steven R
Chamaillard Mathias
Satsangi Jack
Cho Judy H
Schreiber Stefan
Daly Mark J
Barrett Jeffrey C
Parkes Miles
Annese Vito
Hakonarson Hakon
Radford-Smith Graham
Duerr Richard H
Vermeire Séverine
Weersma Rinse K
Rioux John D
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.764
Published
2011-03-00
Epub
2011-00-06
Pages
246-52
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC3084597
Subset
IM
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PubMed source DOI: 10.1038/ng.764 PMC Full Text View journal details
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