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PMID: 21482771 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Genome-wide nested association mapping of quantitative resistance to northern leaf blight in maize.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 108 ·No. 17 ·2011-04-26 ·Pages 6893-8

Poland JA, Bradbury PJ, Buckler ES, Nelson RJ

Abstract

Quantitative resistance to plant pathogens, controlled by multiple loci of small effect, is important for food production, food security, and food safety but is poorly understood. To gain insights into the genetic architecture of quantitative resistance in maize, we evaluated a 5,000-inbred-line nested association mapping population for resistance to northern leaf blight, a maize disease of global economic importance. Twenty-nine quantitative trait loci were identified, and most had multiple alleles. The large variation in resistance phenotypes could be attributed to the accumulation of numerous loci of small additive effects. Genome-wide nested association mapping, using 1.6 million SNPs, identified multiple candidate genes related to plant defense, including receptor-like kinase genes similar to those involved in basal defense. These results are consistent with the hypothesis that quantitative disease resistance in plants is conditioned by a range of mechanisms and could have considerable mechanistic overlap with basal resistance.

MeSH Terms
Plant Diseases/genetics,microbiology Plant Leaves/genetics,microbiology Polymorphism, Single Nucleotide Quantitative Trait, Heritable Zea mays/genetics,microbiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Poland Jesse A
Department of Plant Breeding and Genetics, Cornell University, Ithaca, NY 14853, USA.
Bradbury Peter J
Buckler Edward S
Nelson Rebecca J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1010894108
Published
2011-04-26
Epub
2011-00-11
Pages
6893-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3084105
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.1010894108 PMC Full Text View journal details
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