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PMID: 21494147 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Pathogenesis and treatment of bronchopulmonary dysplasia.

Current opinion in pediatrics ·Vol. 23 ·No. 3 ·2011-06-00 ·Pages 305-13

Gien J, Kinsella JP

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of infancy affecting mostly premature infants with significant morbidity and mortality. Improved survival of very immature infants has led to increased numbers of infants with this disorder. Acute and chronic lung injury and impaired postnatal lung growth are thought to be responsible for the development of BPD. Whereas changes in clinical practice have improved the clinical course and outcomes for infants with BPD, over the past decade, the overall incidence of BPD has not changed. This review will describe the prenatal and postnatal factors that contribute to the pathogenesis of BPD as well as current and experimental therapies for treatment of BPD. The factors that contribute to the pathogenesis of BPD are well described; however, recent studies have better defined how these factors modulate lung growth. Inflammation, proinflammatory cytokines and altered angiogenic gene signaling contribute to lung injury and impair prenatal and postnatal lung growth resulting in BPD; however, to date no therapy has been identified that potently and consistently prevents or reverses their effects on lung growth. We will discuss the cell signaling pathways affected in BPD and current therapies available for modulating these pathways. Despite current advances in neonatal care, BPD remains a heavy burden on healthcare resources. New treatments directed at either reducing lung injury or improving lung growth are under study.

MeSH Terms
Adrenal Cortex Hormones/therapeutic use Bronchopulmonary Dysplasia/etiology,physiopathology,prevention & control,therapy Humans Infant, Newborn Infant, Premature Transforming Growth Factor beta1/metabolism Vascular Endothelial Growth Factor A/metabolism
Chemicals
Adrenal Cortex Hormones Transforming Growth Factor beta1 Vascular Endothelial Growth Factor A
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gien Jason
The Pediatric Heart Lung Center, Section of Neonatology, University of Colorado School of Medicine, Aurora, USA. [email protected]
Kinsella John P
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Article Info
Journal
Current opinion in pediatrics
Abbr.
Curr Opin Pediatr
ISSN
1531-698X
DOI
10.1097/MOP.0b013e328346577f
Email
[email protected]
Published
2011-06-00
Pages
305-13
Language
English
Region
United States
NLM ID
9000850
PMCID
PMC3767848
Subset
IM
Grants
NHLBI NIH HHS · K08 HL102261 · United States
NHLBI NIH HHS · 1K08HL102261 · United States
External Links
PubMed source DOI: 10.1097/MOP.0b013e328346577f PMC Full Text View journal details
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