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PMID: 21502959 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mechanisms and functions of Hedgehog signalling across the metazoa.

Nature reviews. Genetics ·Vol. 12 ·No. 6 ·2011-06-00 ·Pages 393-406

Ingham PW, Nakano Y, Seger C

Abstract

Hedgehog proteins constitute one of a small number of families of secreted signals that have a central role in the development of metazoans. Genetic analyses in flies, fish and mice have uncovered the major components of the pathway that transduces Hedgehog signals, and recent genome sequence projects have provided clues about its evolutionary origins. In this Review we provide an updated overview of the mechanisms and functions of this signalling pathway, highlighting the conserved and divergent features of the pathway, as well as some of the common themes in its deployment that have emerged from recent studies.

MeSH Terms
Animals Cilia/metabolism Drosophila melanogaster Gene Expression Regulation Genome Hedgehog Proteins/genetics,metabolism Humans Ligands Lipids/chemistry Mice Models, Genetic Phylogeny Protein Structure, Tertiary Signal Transduction Transcription Factors/metabolism
Chemicals
Hedgehog Proteins Ligands Lipids Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ingham Philip W
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore. [email protected]
Nakano Yoshiro
Seger Claudia
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2984
Email
[email protected]
Published
2011-06-00
Epub
2011-00-19
Pages
393-406
Language
English
Region
England
NLM ID
100962779
Subset
IM
External Links
PubMed source DOI: 10.1038/nrg2984 View journal details
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