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PMID: 21526222
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Journal Article
Research Support, N.I.H., Extramural
A user's guide to the encyclopedia of DNA elements (ENCODE).
Abstract
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
MeSH Terms
Base Sequence
Chromatin/metabolism
Conserved Sequence
DNA Methylation
DNA-Binding Proteins/genetics,metabolism
Databases, Nucleic Acid
Gene Components
Gene Expression Regulation
Genome, Human
Humans
Internet
Models, Genetic
Quality Control
RNA, Messenger/genetics
RNA-Binding Proteins/genetics,metabolism
Chemicals
Chromatin
DNA-Binding Proteins
RNA, Messenger
RNA-Binding Proteins
Investigators
361 investigators, click to expand
Conflict of Interest
The authors have declared that no competing interests exist.
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Article Info
Journal
PLoS biology
Abbr.
PLoS Biol
ISSN
1545-7885
Email
Published
2011-04-00
Epub
2011-00-19
Pages
e1001046
Language
English
Region
United States
NLM ID
101183755
PMCID
PMC3079585
Subset
IM
Grants
NHGRI NIH HHS · R01 HG004037 · United States
NHGRI NIH HHS · RC2 HG005573 · United States
NHGRI NIH HHS · R01 HG003143 · United States
NIDDK NIH HHS · R01 DK054369 · United States
Wellcome Trust · 095908 · United Kingdom
NIDDK NIH HHS · R01 DK065806 · United States
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