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PMID: 21537017 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Five-minute exposure to caspofungin results in prolonged postantifungal effects and eliminates the paradoxical growth of Candida albicans.

Antimicrobial agents and chemotherapy ·Vol. 55 ·No. 7 ·2011-07-00 ·Pages 3598-602

Shields RK, Nguyen MH, Press EG, Clancy CJ

Abstract

We studied the impact of brief caspofungin exposures on postantifungal effects (PAFEs) and paradoxical effects for five Candida albicans isolates. In time-kill studies, caspofungin at 4× and 16× the MIC resulted in significant killing of all isolates. Caspofungin at 8 μg/ml resulted in lower levels of killing, and paradoxical effects were evident with 4 isolates. Caspofungin exposures of 5 to 60 min caused prolonged, concentration-dependent killing that approached or exceeded the results seen with time-kill experiments and eliminated paradoxical growth.

MeSH Terms
Antifungal Agents/pharmacology Candida albicans/drug effects,growth & development Caspofungin Echinocandins/pharmacology Lipopeptides Microbial Sensitivity Tests
Chemicals
Antifungal Agents Echinocandins Lipopeptides Caspofungin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Shields Ryan K
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nguyen M Hong
Press Ellen G
Clancy Cornelius J
References (20)
20 references, click to expand
  1. In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species.
    Antimicrob Agents Chemother. 2010 Jun;54(6):2497-506 PMID: 20385855
  2. Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans.
    Antimicrob Agents Chemother. 2000 Apr;44(4):1108-11 PMID: 10722525
  3. General guidelines for the clinical evaluation of anti-infective drug products. Infectious Diseases Society of America and the Food and Drug Administration.
    Clin Infect Dis. 1992 Nov;15 Suppl 1:S5-32 PMID: 1477251
  4. A Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis.
    Clin Infect Dis. 2009 Jun 15;48(12):1676-84 PMID: 19419331
  5. Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity.
    Antimicrob Agents Chemother. 2005 Dec;49(12):5058-68 PMID: 16304173
  6. Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice.
    Antimicrob Agents Chemother. 2000 Sep;44(9):2310-8 PMID: 10952573
  7. Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum.
    Antimicrob Agents Chemother. 2011 Jun;55(6):2641-7 PMID: 21422223
  8. Anidulafungin is fungicidal and exerts a variety of postantifungal effects against Candida albicans, C. glabrata, C. parapsilosis, and C. krusei isolates.
    Antimicrob Agents Chemother. 2009 Aug;53(8):3347-52 PMID: 19364856
  9. In vitro pharmacodynamic properties of MK-0991 determined by time-kill methods.
    Diagn Microbiol Infect Dis. 1999 Feb;33(2):75-80 PMID: 10091029
  10. Mechanisms of the post-antibiotic effects induced by rifampicin and gentamicin in Escherichia coli.
    J Antimicrob Chemother. 2006 Aug;58(2):444-8 PMID: 16735423
  11. Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis.
    J Antimicrob Chemother. 2008 May;61(5):1140-4 PMID: 18305201
  12. Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect.
    Antimicrob Agents Chemother. 2005 Mar;49(3):1206-8 PMID: 15728929
  13. Once-weekly micafungin therapy is as effective as daily therapy for disseminated candidiasis in mice with persistent neutropenia.
    Antimicrob Agents Chemother. 2007 Mar;51(3):968-74 PMID: 17194830
  14. A comparative study of the post-antifungal effect (PAFE) of amphotericin B, triazoles and echinocandins on Aspergillus fumigatus and Candida albicans.
    J Antimicrob Chemother. 2004 Feb;53(2):386-9 PMID: 14729762
  15. Assessment of the paradoxical effect of caspofungin in therapy of candidiasis.
    Antimicrob Agents Chemother. 2006 Apr;50(4):1293-7 PMID: 16569843
  16. Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis.
    Clin Infect Dis. 2007 Oct 1;45(7):883-93 PMID: 17806055
  17. Characterising the post-antifungal effects of micafungin against Candida albicans, Candida glabrata, Candida parapsilosis and Candida krusei isolates.
    Int J Antimicrob Agents. 2010 Jan;35(1):80-4 PMID: 19889519
  18. Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations.
    Mol Gen Genet. 1984;198(2):179-82 PMID: 6394964
  19. Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.
    Antimicrob Agents Chemother. 2006 Jul;50(7):2569-72 PMID: 16801448
  20. In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies.
    Antimicrob Agents Chemother. 2004 Nov;48(11):4453-6 PMID: 15504881
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
1098-6596
DOI
10.1128/AAC.00095-11
Published
2011-07-00
Epub
2011-00-02
Pages
3598-602
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC3122450
Subset
IM
Grants
NCATS NIH HHS · KL2 TR000146 · United States
NCATS NIH HHS · UL1 TR000005 · United States
Corrections
CommentIn
PMID: 22568712
External Links
PubMed source DOI: 10.1128/AAC.00095-11 PMC Full Text View journal details
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