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PMID: 2153969 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 3 ·1990-02-00 ·Pages 1124-8

Vallés AM, Boyer B, Badet J, Tucker GC, Barritault D, Thiery JP

Abstract

During normal embryogenesis and neoplastic transformation epithelia change their state of differentiation and degree of cohesiveness. It is thus essential to identify the signals modulating these transitions. We report here that acidic fibroblast growth factor (FGF) induces cells derived from a rat bladder carcinoma to lose their epithelial character and to acquire some properties typical of mesenchymal cells. The structurally related basic FGF did not have such an effect; both factors, however, had a mitogenic activity for these cells. Two distinct populations of receptors for acidic FGF and basic FGF were distinguished by their ligand-binding characteristics. The observations that both acidic and basic FGFs had a mitogenic effect on NBT-II cells and that only acidic FGF caused cell dissociation and dispersion strongly suggest that these two biological activities could be medicated through distinct signaling pathways.

MeSH Terms
Animals Cell Division/drug effects Cell Line Cell Movement/drug effects Epithelial Cells Epithelium/drug effects,physiology Fibroblast Growth Factors/metabolism,pharmacology Kinetics Rats Receptors, Cell Surface/metabolism Receptors, Fibroblast Growth Factor Recombinant Proteins/metabolism,pharmacology Tumor Cells, Cultured/cytology,drug effects,physiology Urinary Bladder Neoplasms
Chemicals
Receptors, Cell Surface Receptors, Fibroblast Growth Factor Recombinant Proteins Fibroblast Growth Factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Vallés A M
Laboratoire de Physiopathologie du Développement, Centre National de la Recherche Scientifique, Paris, France.
Boyer B
Badet J
Tucker G C
Barritault D
Thiery J P
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.3.1124
Published
1990-02-00
Pages
1124-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53423
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.87.3.1124 PMC Full Text View journal details
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