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PMID: 21555211 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Lipid transfer and signaling at organelle contact sites: the tip of the iceberg.

Current opinion in cell biology ·Vol. 23 ·No. 4 ·2011-08-00 ·Pages 458-63

Toulmay A, Prinz WA

Abstract

Membrane contact sites (MCSs) are formed by the close apposition of membranes of two organelles. They are zones where signals and small molecules, such as lipids and calcium, are exchanged between intracellular compartments. The past few years have seen considerable progress in our understanding of how MCSs form and facilitate the exchange of lipids and signals. Here we summarize what has been learned about MCSs between the endoplamic reticulum (ER) and the plasma membrane, the ER and mitochondria, and the ER and endosomes or lysosomes. These findings suggest that we are just beginning to understand how MCSs form and function.

MeSH Terms
Animals Cell Membrane/metabolism Endoplasmic Reticulum/metabolism Endosomes/metabolism Humans Intracellular Membranes/metabolism Lipid Metabolism Lysosomes/metabolism Mitochondrial Membranes/metabolism Organelles/metabolism Signal Transduction Yeasts/cytology,metabolism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Toulmay Alexandre
Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Prinz William A
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2011.04.006
Published
2011-08-00
Pages
458-63
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3148286
Subset
IM
Grants
Intramural NIH HHS · ZIA DK060004-09 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2011.04.006 PMC Full Text View journal details
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