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PMID: 20823909 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Non-vesicular lipid transport by lipid-transfer proteins and beyond.

Nature reviews. Molecular cell biology ·Vol. 11 ·No. 10 ·2010-10-00 ·Pages 739-50

Lev S

Abstract

The movement of lipids within and between intracellular membranes is mediated by different lipid transport mechanisms and is crucial for maintaining the identities of different cellular organelles. Non-vesicular lipid transport has a crucial role in intracellular lipid trafficking and distribution, but its underlying mechanisms remain unclear. Lipid-transfer proteins (LTPs), which regulate diverse lipid-mediated cellular processes and accelerate vectorial transport of lipid monomers between membranes in vitro, could potentially mediate non-vesicular intracellular lipid trafficking. Understanding the mechanisms by which lipids are transported and distributed between cellular membranes, and elucidating the role of LTPs in intracellular lipid transport and homeostasis, are currently subjects of intensive study.

MeSH Terms
Animals Biological Transport Carrier Proteins/metabolism Cholesterol/metabolism Diffusion Diglycerides/metabolism Golgi Apparatus/metabolism Homeostasis Intracellular Membranes/metabolism Lipid Bilayers/metabolism Lipids/physiology
Chemicals
Carrier Proteins Diglycerides Lipid Bilayers Lipids lipid transfer protein Cholesterol
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lev Sima
Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel. [email protected]
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2971
Email
[email protected]
Published
2010-10-00
Epub
2010-00-08
Pages
739-50
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm2971 View journal details
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