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PMID: 2157668 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vivo activation of macrophage oxidative burst activity by cytokines and amphotericin B.

Infection and immunity ·Vol. 58 ·No. 5 ·1990-05-00 ·Pages 1296-300

Wolf JE, Massof SE

Abstract

Alterations in macrophage oxidative burst activity following in vivo administration of recombinant murine gamma interferon (IFN-gamma), recombinant murine tumor necrosis factor alpha, and the antifungal antibiotic amphotericin B were investigated. Mice were given intraperitoneal injections of these agents alone and in combination, and the oxidative responses of their resident peritoneal macrophages to challenge with Histoplasma capsulatum or zymosan particles were measured 1 to 5 days later. Various degrees of enhanced oxidative burst activity were achieved following treatment with each agent. However, a synergistic response was observed only when mice were treated with the combination of recombinant murine IFN-gamma and amphotericin B. These results not only confirm the dual role of amphotericin as an antifungal agent and as an immunomodulator but also suggest that IFN-gamma may serve as a useful adjunct in the treatment of intracellular fungal infections.

MeSH Terms
Amphotericin B/pharmacology Animals Biological Factors/pharmacology Cytokines Drug Synergism Female Histoplasma/immunology Interferon-gamma/pharmacology Macrophages/physiology Mice Mice, Inbred AKR Oxidation-Reduction Phagocytosis/drug effects Recombinant Proteins Superoxides/metabolism Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Biological Factors Cytokines Recombinant Proteins Tumor Necrosis Factor-alpha Superoxides Amphotericin B Interferon-gamma
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wolf J E
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Massof S E
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.58.5.1296-1300.1990
Published
1990-05-00
Pages
1296-300
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC258623
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.58.5.1296-1300.1990 PMC Full Text View journal details
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