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PMID: 2161952 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri.

Journal of virology ·Vol. 64 ·No. 7 ·1990-07-00 ·Pages 3509-15

Geck P, Whitaker SA, Medveczky MM, Medveczky PG

Abstract

Sequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.

MeSH Terms
Base Sequence Blotting, Northern Blotting, Southern Cloning, Molecular Collagen/genetics DNA, Viral/genetics Gene Expression Genes, Viral Herpesvirus 2, Saimiriine/classification,genetics Molecular Sequence Data RNA, Messenger/genetics Restriction Mapping Sequence Homology, Nucleic Acid Viral Structural Proteins/genetics
Chemicals
DNA, Viral RNA, Messenger Viral Structural Proteins Collagen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Geck P
Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
Whitaker S A
Medveczky M M
Medveczky P G
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.7.3509-3515.1990
Published
1990-07-00
Pages
3509-15
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC249618
Subset
IM
Grants
NIAID NIH HHS · AI21129 · United States
NCI NIH HHS · R01 CA39653 · United States
NCI NIH HHS · R01 CA43264 · United States
Databases
GENBANK
M31964
Corrections
ErratumIn
PMID: 1658399
External Links
PubMed source DOI: 10.1128/JVI.64.7.3509-3515.1990 PMC Full Text View journal details
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