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PMID: 21685931 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

From the stochasticity of molecular processes to the variability of synaptic transmission.

Nature reviews. Neuroscience ·Vol. 12 ·No. 7 ·2011-06-20 ·Pages 375-87

Ribrault C, Sekimoto K, Triller A

Abstract

The variability of the postsynaptic response following a single action potential arises from two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to neurotransmitter release has variable timing and amplitude. At individual synapses, the number of molecules of a given type that are involved in these processes is small enough that the stochastic (random) properties of molecular events cannot be neglected. How the stochasticity of molecular processes contributes to the variability of synaptic transmission, its sensitivity and its robustness to molecular fluctuations has important implications for our understanding of the mechanistic basis of synaptic transmission and of synaptic plasticity.

MeSH Terms
Animals Calcium Channels/physiology Models, Neurological Neurons/cytology,physiology Neurotransmitter Agents/metabolism Presynaptic Terminals/physiology Receptors, Cell Surface/physiology Stochastic Processes Synapses/physiology Synaptic Transmission/genetics Time Factors
Chemicals
Calcium Channels Neurotransmitter Agents Receptors, Cell Surface
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ribrault Claire
Laboratoire Matières et Systèmes Complexes, CNRS-UMR7057, Université Paris 7, F-75205 Paris cedex 13, France.
Sekimoto Ken
Triller Antoine
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-0048
DOI
10.1038/nrn3025
Published
2011-06-20
Epub
2011-00-20
Pages
375-87
Language
English
Region
England
NLM ID
100962781
Subset
IM
External Links
PubMed source DOI: 10.1038/nrn3025 View journal details
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