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PMID: 2412607 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release.

Biophysical journal ·Vol. 48 ·No. 3 ·1985-09-00 ·Pages 485-98

Simon SM, Llinás RR

Abstract

Quantitative modeling indicates that, in presynaptic terminals, the intracellular calcium concentration profile during inward calcium current is characterized by discrete peaks of calcium immediately adjacent to the calcium channels. This restriction of intracellular calcium concentration suggests a remarkably well specified intracellular architecture such that calcium, as a second messenger, may regulate particular intracellular domains with a great degree of specificity.

MeSH Terms
Animals Calcium/metabolism Cytosol/metabolism Decapodiformes Diffusion Ion Channels/physiology Kinetics Membrane Potentials Models, Biological Software Synapses/physiology
Chemicals
Ion Channels Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Simon S M
Llinás R R
References (39)
39 references, click to expand
  1. Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells.
    Proc Natl Acad Sci U S A. 1976 Jul;73(7):2520-3 PMID: 1065905
  2. Presynaptic calcium currents and their relation to synaptic transmission: voltage clamp study in squid giant synapse and theoretical model for the calcium gate.
    Proc Natl Acad Sci U S A. 1976 Aug;73(8):2918-22 PMID: 183215
  3. Artificial deciliation causes loss of calcium-dependent responses in Paramecium.
    Nature. 1976 Nov 11;264(5582):170-2 PMID: 995200
  4. Calcium diffusion in transient and steady states in muscle.
    Biophys J. 1977 Oct;20(1):113-36 PMID: 901900
  5. Localization of calcium channels in Paramecium caudatum.
    J Physiol. 1977 Sep;271(1):119-33 PMID: 915829
  6. Depolarization-release coupling systems in neurons.
    Neurosci Res Program Bull. 1977 Dec;15(4):555-687 PMID: 24819
  7. Uptake and binding of calcium by axoplasm isolated from giant axons of Loligo and Myxicola.
    J Physiol. 1978 Mar;276:103-25 PMID: 650429
  8. Calmodulin--an intracellular calcium receptor.
    Nature. 1980 May 8;285(5760):73-7 PMID: 6990273
  9. A theoretical explanation for some effects of calcium on the facilitation of neurotransmitter release.
    J Theor Biol. 1980 May 7;84(1):3-29 PMID: 6106090
  10. Calcium conductances in Purkinje cell dendrites: their role in development and integration.
    Prog Brain Res. 1979;51:323-34 PMID: 551484
  11. Effect of glycerol treatment on the calcium current of frog skeletal muscle.
    J Physiol. 1980 Aug;305:87-96 PMID: 6969308
  12. Presynaptic calcium currents in squid giant synapse.
    Biophys J. 1981 Mar;33(3):289-321 PMID: 7225510
  13. Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse.
    Biophys J. 1981 Mar;33(3):323-51 PMID: 6261850
  14. Intracellular calcium accumulation during depolarization in a molluscan neurone.
    J Physiol. 1980 Nov;308:259-85 PMID: 7230017
  15. Calcium transients recorded with arsenazo III in the presynaptic terminal of the squid giant synapse.
    Proc R Soc Lond B Biol Sci. 1981 May 22;212(1187):197-211 PMID: 6113595
  16. A theoretical study of calcium entry in nerve terminals, with application to neurotransmitter release.
    J Theor Biol. 1981 Jul 7;91(1):125-69 PMID: 6117676
  17. Are the presynaptic membrane particles the calcium channels?
    Proc Natl Acad Sci U S A. 1981 Nov;78(11):7210-3 PMID: 6273920
  18. Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse.
    J Physiol. 1982 Feb;323:173-93 PMID: 6284915
  19. Transmission by presynaptic spike-like depolarization in the squid giant synapse.
    Proc Natl Acad Sci U S A. 1982 Apr;79(7):2415-9 PMID: 6954549
  20. Calcium-dependence of catecholamine release from bovine adrenal medullary cells after exposure to intense electric fields.
    J Membr Biol. 1982;68(2):107-40 PMID: 6809949
  21. Localization of voltage-sensitive calcium channels along developing neurites: their possible role in regulating neurite elongation.
    Dev Biol. 1982 Dec;94(2):351-65 PMID: 6295852
  22. Variation of intracellular Ca2+ following Ca2+ current in heart. A theoretical study of ionic diffusion inside a cylindrical cell.
    Biophys J. 1983 Mar;41(3):341-8 PMID: 6838972
  23. Presynaptic calcium diffusion and the time courses of transmitter release and synaptic facilitation at the squid giant synapse.
    J Neurosci. 1983 Jun;3(6):1263-9 PMID: 6133920
  24. Presynaptic currents in mouse motor endings.
    J Physiol. 1982 Dec;333:619-36 PMID: 6304288
  25. Divalent cations differentially support transmitter release at the squid giant synapse.
    J Physiol. 1984 Jan;346:257-71 PMID: 6142104
  26. Dynamics of intracellular calcium and its possible relationship to phasic transmitter release and facilitation at the frog neuromuscular junction.
    J Neurosci. 1984 Mar;4(3):803-11 PMID: 6142934
  27. Kinetics of calcium-dependent inactivation of calcium current in voltage-clamped neurones of Aplysia californica.
    J Physiol. 1984 Feb;347:279-300 PMID: 6323696
  28. Transmission at voltage-clamped giant synapse of the squid: evidence for cooperativity of presynaptic calcium action.
    Proc Natl Acad Sci U S A. 1985 Jan;82(2):622-5 PMID: 2982166
  29. Movements of labelled calcium in squid giant axons.
    J Physiol. 1957 Sep 30;138(2):253-81 PMID: 13526124
  30. Electrical changes in pre- and postsynaptic axons of the giant synapse of Loligo.
    J Gen Physiol. 1962 Jul;45:1181-93 PMID: 13919241
  31. A study of synaptic transmission in the absence of nerve impulses.
    J Physiol. 1967 Sep;192(2):407-36 PMID: 4383089
  32. Co-operative action a calcium ions in transmitter release at the neuromuscular junction.
    J Physiol. 1967 Nov;193(2):419-32 PMID: 6065887
  33. A dual effect of calcium ions on neuromuscular facilitation.
    J Physiol. 1968 Mar;195(2):471-80 PMID: 4296698
  34. The role of calcium in neuromuscular facilitation.
    J Physiol. 1968 Mar;195(2):481-92 PMID: 4296699
  35. Synaptic current at the squid giant synapse.
    Science. 1969 Oct 24;166(3904):510-2 PMID: 4309626
  36. Depolarization and calcium entry in squid giant axons.
    J Physiol. 1971 Nov;218(3):709-55 PMID: 5133953
  37. Calcium inward currents in internally perfused giant axons.
    J Physiol. 1973 Nov;235(1):225-65 PMID: 4778139
  38. Depression and recovery of transmission at the squid giant synapse.
    J Physiol. 1975 Feb;245(1):13-32 PMID: 165284
  39. A quantitative description of tetanic and post-tetanic potentiation of transmitter release at the frog neuromuscular junction.
    J Physiol. 1975 Feb;245(1):183-208 PMID: 165286
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(85)83804-2
Published
1985-09-00
Pages
485-98
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1329362
Subset
IM
Grants
NINDS NIH HHS · NS-14014 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(85)83804-2 PMC Full Text View journal details
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