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PMID: 21701570 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome-wide association of BMI in African Americans.

Obesity (Silver Spring, Md.) ·Vol. 20 ·No. 3 ·2012-03-00 ·Pages 622-7

Ng MC, Hester JM, Wing MR, Li J, Xu J, Hicks PJ, Roh BH, Lu L, Divers J, Langefeld CD, Freedman BI, Palmer ND, Bowden DW

Abstract

Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with obesity in Europeans but results in other ethnicities are less convincing. Here, we report a two-stage GWAS of BMI in African Americans. The GWAS was performed using the Affymetrix 6.0 platform in 816 nondiabetic and 899 diabetic nephropathy subjects. 746,626 single-nucleotide polymorphisms (SNPs) were tested for association with BMI after adjustment for age, gender, disease status, and population structure. Sixty high scoring SNPs that showed nominal association in both GWAS cohorts were further replicated in 3,274 additional subjects in four replication cohorts and a meta-analysis was computed. Meta-analysis of 4,989 subjects revealed five SNPs (rs6794092, rs268972, rs2033195, rs815611, and rs6088887) at four loci showing consistent associations in both GWAS (P < 0.0001) and replication cohorts (P < 0.05) with combined P values range from 2.4 × 10(-6) to 5 × 10(-5). These loci are located near PP13439-TMEM212, CDH12, MFAP3-GALNT10, and FER1L4 and had effect sizes between 0.091 and 0.167 s.d. unit (or 0.67-1.24 kg/m(2)) of BMI for each copy of the effect allele. Our findings suggest the presence of novel loci potentially associated with adiposity in African Americans. Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations.

MeSH Terms
African Americans/genetics Body Mass Index Cohort Studies Diabetic Nephropathies/epidemiology,ethnology,genetics Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Middle Aged Obesity/epidemiology,ethnology,genetics Polymorphism, Single Nucleotide Reproducibility of Results
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Ng Maggie C Y
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. [email protected]
Hester Jessica M
Wing Maria R
Li Jiang
Xu Jianzhao
Hicks Pamela J
Roh Bong H
Lu Lingyi
Divers Jasmin
Langefeld Carl D
Freedman Barry I
Palmer Nichole D
Bowden Donald W
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Article Info
Journal
Obesity (Silver Spring, Md.)
Abbr.
Obesity (Silver Spring)
ISSN
1930-739X
DOI
10.1038/oby.2011.154
Email
[email protected]
Published
2012-03-00
Epub
2011-00-23
Pages
622-7
Language
English
Region
United States
NLM ID
101264860
PMCID
PMC3291470
Subset
IM
Grants
NHLBI NIH HHS · R01 HL56266 · United States
NHLBI NIH HHS · R01 HL060944 · United States
NIDDK NIH HHS · R01 DK087914 · United States
NCRR NIH HHS · M01 RR007122 · United States
NCRR NIH HHS · M01 RR07122 · United States
NIDDK NIH HHS · R01 DK053591 · United States
NIDDK NIH HHS · R01 DK070941-01A1 · United States
NHLBI NIH HHS · R01 HL061210 · United States
NIDDK NIH HHS · R01 DK070941 · United States
PHS HHS · HHSC268200782096C · United States
NIDDK NIH HHS · K99 DK081350 · United States
NIDDK NIH HHS · R01 DK066358 · United States
External Links
PubMed source DOI: 10.1038/oby.2011.154 PMC Full Text View journal details
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