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PMID: 21725310 Published · epublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals.

Nature genetics ·Vol. 43 ·No. 8 ·2011-07-03 ·Pages 745-52

Ju YS, Kim JI, Kim S, Hong D, Park H, Shin JY, Lee S, Lee WC, Kim S, Yu SB, Park SS, Seo SH, Yun JY, Kim HJ, Lee DS, Yavartanoo M, Kang HP, Gokcumen O, Govindaraju DR, Jung JH, Chong H, Yang KS, Kim H, Lee C, Seo JS

Abstract

Massively parallel sequencing technologies have identified a broad spectrum of human genome diversity. Here we deep sequenced and correlated 18 genomes and 17 transcriptomes of unrelated Korean individuals. This has allowed us to construct a genome-wide map of common and rare variants and also identify variants formed during DNA-RNA transcription. We identified 9.56 million genomic variants, 23.2% of which appear to be previously unidentified. From transcriptome sequencing, we discovered 4,414 transcripts not previously annotated. Finally, we revealed 1,809 sites of transcriptional base modification, where the transcriptional landscape is different from the corresponding genomic sequences, and 580 sites of allele-specific expression. Our findings suggest that a considerable number of unexplored genomic variants still remain to be identified in the human genome, and that the integrated analysis of genome and transcriptome sequencing is powerful for understanding the diversity and functional aspects of human genomic variants.

MeSH Terms
Female Gene Expression Profiling Genome, Human High-Throughput Nucleotide Sequencing Humans Korea Male Polymorphism, Single Nucleotide/genetics Sequence Analysis, DNA Sequence Analysis, RNA
Authors & Affiliations
25 authors, click to expand affiliations / ORCID
Ju Young Seok
Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul, Korea.
Kim Jong-Il
Kim Sheehyun
Hong Dongwan
Park Hansoo
Shin Jong-Yeon
Lee Seungbok
Lee Won-Chul
Kim Sujung
Yu Saet-Byeol
Park Sung-Soo
Seo Seung-Hyun
Yun Ji-Young
Kim Hyun-Jin
Lee Dong-Sung
Yavartanoo Maryam
Kang Hyunseok Peter
Gokcumen Omer
Govindaraju Diddahally R
Jung Jung Hee
Chong Hyonyong
Yang Kap-Seok
Kim Hyungtae
Lee Charles
Seo Jeong-Sun
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
Published
2011-07-03
Epub
2011-00-03
Pages
745-52
Language
English
Region
United States
NLM ID
9216904
Subset
IM
Grants
NHGRI NIH HHS · P41HG4221 · United States
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