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PMID: 21727133 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Induced pluripotent stem cells for modelling human diseases.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 366 ·No. 1575 ·2011-08-12 ·Pages 2274-85

Unternaehrer JJ, Daley GQ

Abstract

Research into the pathophysiological mechanisms of human disease and the development of targeted therapies have been hindered by a lack of predictive disease models that can be experimentally manipulated in vitro. This review describes the current state of modelling human diseases with the use of human induced pluripotent stem (iPS) cell lines. To date, a variety of neurodegenerative diseases, haematopoietic disorders, metabolic conditions and cardiovascular pathologies have been captured in a Petri dish through reprogramming of patient cells into iPS cells followed by directed differentiation of disease-relevant cells and tissues. However, realizing the true promise of iPS cells for advancing our basic understanding of disease and ultimately providing novel cell-based therapies will require more refined protocols for generating the highly specialized cells affected by disease, coupled with strategies for drug discovery and cell transplantation.

MeSH Terms
Cell Culture Techniques Cell Line Epigenesis, Genetic Gene Expression Regulation/physiology Humans Induced Pluripotent Stem Cells/physiology Transcription Factors/genetics,metabolism
Chemicals
Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Unternaehrer Juli J
Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Children's Hospital Boston, Boston, MA 02115, USA.
Daley George Q
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
1471-2970
DOI
10.1098/rstb.2011.0017
Published
2011-08-12
Pages
2274-85
Language
English
Region
England
NLM ID
7503623
PMCID
PMC3130418
Subset
IM
Grants
NHLBI NIH HHS · U01-HL100001 · United States
NHLBI NIH HHS · RC2-HL102815 · United States
NIDDK NIH HHS · R01 DK070055 · United States
Howard Hughes Medical Institute · United States
NHLBI NIH HHS · T32-HL07623-23 · United States
NHLBI NIH HHS · T32 HL007623 · United States
NIDDK NIH HHS · R01-DK59270 · United States
NIDDK NIH HHS · R01 DK70055 · United States
NIDDK NIH HHS · R01 DK059279 · United States
NHLBI NIH HHS · U01 HL100001 · United States
NHLBI NIH HHS · RC2 HL102815 · United States
External Links
PubMed source DOI: 10.1098/rstb.2011.0017 PMC Full Text View journal details
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