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PMID: 2174014 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Molecular structure of frizzled, a Drosophila tissue polarity gene.

Genetics ·Vol. 126 ·No. 2 ·1990-10-00 ·Pages 401-16

Adler PN, Vinson C, Park WJ, Conover S, Klein L

Abstract

The function of the frizzled (fz) locus is required to coordinate the cytoskeletons of pupal epidermal cells so that a parallel array of cuticular hairs and bristles is produced. We report here the molecular cloning and characterization of the fz locus. The locus is very large. Mutations that inactivate the gene are spread over 100 kb of genomic DNA. The major mRNA product of the gene is a 4-kb RNA that is encoded by 5 exons spread over more than 90 kb of genomic DNA. Conceptual translation of this mRNA indicates that it encodes an integral membrane protein that is likely to contain both extracellular and cytoplasmic domains.

Related Genes
fz
MeSH Terms
Amino Acid Sequence Animals Base Sequence Blotting, Northern Chromosome Mapping Cloning, Molecular DNA Transposable Elements Drosophila Proteins Drosophila melanogaster/anatomy & histology,genetics Female Frizzled Receptors Genes Insect Hormones/genetics Male Membrane Proteins/genetics Molecular Sequence Data Mutation Phenotype Polymerase Chain Reaction Protein Biosynthesis Receptors, G-Protein-Coupled Restriction Mapping
Chemicals
DNA Transposable Elements Drosophila Proteins Frizzled Receptors Insect Hormones Membrane Proteins Receptors, G-Protein-Coupled fz protein, Drosophila
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Adler P N
Biology Department, University of Virginia, Charlottesville 22901.
Vinson C
Park W J
Conover S
Klein L
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/126.2.401
Published
1990-10-00
Pages
401-16
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1204194
Subset
IM
Grants
NIGMS NIH HHS · R01 GM037163 · United States
NICHD NIH HHS · HD0-7192 · United States
NICHD NIH HHS · KHD0-0361 · United States
NIGMS NIH HHS · R01-GM37136 · United States
Databases
GENBANK
X54646, X54647, X54648
External Links
PubMed source DOI: 10.1093/genetics/126.2.401 PMC Full Text View journal details
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