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PMID: 21779009 Published · epublish English Journal Article Research Support, N.I.H., Extramural Review

Chemotaxis in cancer.

Nature reviews. Cancer ·Vol. 11 ·No. 8 ·2011-07-22 ·Pages 573-87

Roussos ET, Condeelis JS, Patsialou A

Abstract

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

MeSH Terms
Animals Cell Movement Chemotaxis Disease Progression Humans Neoplasms/physiopathology Prognosis Tumor Cells, Cultured
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Roussos Evanthia T
Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
Condeelis John S
Patsialou Antonia
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3078
Published
2011-07-22
Epub
2011-00-22
Pages
573-87
Language
English
Region
England
NLM ID
101124168
PMCID
PMC4030706
Subset
IM
Grants
NCI NIH HHS · P01 CA100324 · United States
NCI NIH HHS · CA100324 · United States
NCI NIH HHS · R01 CA113395 · United States
NCI NIH HHS · CA113395 · United States
NCI NIH HHS · CA150344 · United States
NCI NIH HHS · R01 CA150344 · United States
External Links
PubMed source DOI: 10.1038/nrc3078 PMC Full Text View journal details
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