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PMID: 21857943 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Voluntary wheel running reverses age-induced changes in hippocampal gene expression.

PloS one ·Vol. 6 ·No. 8 ·2011-00-00 ·Pages e22654

Kohman RA, Rodriguez-Zas SL, Southey BR, Kelley KW, Dantzer R, Rhodes JS

Abstract

Normal aging alters expression of numerous genes within the brain. Some of these transcription changes likely contribute to age-associated cognitive decline, reduced neural plasticity, and the higher incidence of neuropathology. Identifying factors that modulate brain aging is crucial for improving quality of life. One promising intervention to counteract negative effects of aging is aerobic exercise. Aged subjects that exercise show enhanced cognitive performance and increased hippocampal neurogenesis and synaptic plasticity. Currently, the mechanisms behind the anti-aging effects of exercise are not understood. The present study conducted a microarray on whole hippocampal samples from adult (3.5-month-old) and aged (18-month-old) male BALB/c mice that were individually housed with or without running wheels for 8 weeks. Results showed that aging altered genes related to chromatin remodeling, cell growth, immune activity, and synapse organization compared to adult mice. Exercise was found to modulate many of the genes altered by aging, but in the opposite direction. For example, wheel running increased expression of genes related to cell growth and attenuated expression of genes involved in immune function and chromatin remodeling. Collectively, findings show that even late-onset exercise may attenuate age-related changes in gene expression and identifies possible pathways through which exercise may exert its beneficial effects.

MeSH Terms
Age Factors Aging/physiology Animals Body Weight/physiology Gene Expression Profiling/methods Hippocampus/metabolism Male Mice Mice, Inbred BALB C Oligonucleotide Array Sequence Analysis/methods Physical Conditioning, Animal/physiology Reverse Transcriptase Polymerase Chain Reaction Transcriptome
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kohman Rachel A
Department of Psychology, Beckman Institute, University of Illinois, Urbana, Illinois, United States of America. [email protected]
Rodriguez-Zas Sandra L
Southey Bruce R
Kelley Keith W
Dantzer Robert
Rhodes Justin S
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0022654
Email
[email protected]
Published
2011-00-00
Epub
2011-00-08
Pages
e22654
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC3152565
Subset
IM
Grants
NIMH NIH HHS · R01 MH083807 · United States
NIDA NIH HHS · R21 DA027548 · United States
NIDA NIH HHS · R01 DA027487 · United States
NIDA NIH HHS · DA027487 · United States
NIDA NIH HHS · P30 DA018310 · United States
NIMH NIH HHS · MH083807 · United States
Databases
GEO
GSE29075
External Links
PubMed source DOI: 10.1371/journal.pone.0022654 PMC Full Text View journal details
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