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PMID: 21878993 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulation of developmental intercellular signalling by intracellular trafficking.

The EMBO journal ·Vol. 30 ·No. 17 ·2011-08-31 ·Pages 3516-26

Shilo BZ, Schejter ED

Abstract

Universal trafficking components within the cell can be recruited to coordinate and regulate the developmental signalling cascades. We will present ways in which the intracellular trafficking machinery is used to affect and modulate the outcome of signal transduction in developmental contexts, thus regulating multicellular development. Each of the signalling components must reach its proper intracellular destination, in a form that is properly folded and modified. In many instances, the ability to bring components together or segregate them into distinct compartments within the cell actually provides the switch mechanism to turn developmental signalling pathways on or off. The review will begin with a focus on the signal-sending cells, and the ways in which ligand trafficking can impinge on the signalling outcome, via processing, endocytosis and recycling. We will then turn to the signal-receiving cell, and discuss mechanisms by which endocytosis can affect the spatial features of the signal, and the compartmentalization of components downstream to the receptor.

MeSH Terms
Animals Cell Membrane/metabolism Drosophila/metabolism,physiology Endocytosis Humans Mice Protein Processing, Post-Translational/physiology Protein Transport Receptors, Notch/metabolism Signal Transduction/physiology
Chemicals
Receptors, Notch
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shilo Ben-Zion
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. [email protected]
Schejter Eyal D
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.1038/emboj.2011.269
Email
[email protected]
Published
2011-08-31
Epub
2011-00-31
Pages
3516-26
Language
English
Region
England
NLM ID
8208664
PMCID
PMC3181488
Subset
IM
External Links
PubMed source DOI: 10.1038/emboj.2011.269 PMC Full Text View journal details
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