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PMID: 21900009 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The ER in 3D: a multifunctional dynamic membrane network.

Trends in cell biology ·Vol. 21 ·No. 12 ·2011-12-00 ·Pages 709-17

Friedman JR, Voeltz GK

Abstract

The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contacts with nearly every other organelle and with the plasma membrane. The 3D structure of the ER is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. In this review, we describe some of the factors that are known to regulate ER structure and discuss how this structural organization and the dynamic nature of the ER membrane network allow it to perform its many different functions.

MeSH Terms
Animals Cell Membrane/metabolism Cell Shape Cytoskeleton/metabolism Endoplasmic Reticulum/metabolism,physiology,ultrastructure Endosomes/metabolism Golgi Apparatus/metabolism Humans Imaging, Three-Dimensional Membrane Fusion Microscopy Models, Biological Organelle Shape Peroxisomes/metabolism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Friedman Jonathan R
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA.
Voeltz Gia K
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2011.07.004
Published
2011-12-00
Epub
2011-00-06
Pages
709-17
Language
English
Region
England
NLM ID
9200566
PMCID
PMC3221873
Subset
IM
Grants
NIGMS NIH HHS · R01 GM083977 · United States
NIGMS NIH HHS · R01 GM083977-03 · United States
NIGMS NIH HHS · T32 GM008759 · United States
NIGMS NIH HHS · GM08759 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2011.07.004 PMC Full Text View journal details
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