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PMID: 21951282 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.

Cell proliferation ·Vol. 44 ·No. 5 ·2011-10-00 ·Pages 391-400

Silva P, Barbosa J, Nascimento AV, Faria J, Reis R, Bousbaa H

Abstract

Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.

MeSH Terms
Anaphase/genetics,physiology Animals Chromosome Segregation/genetics,physiology Genes, cdc Humans Kinetochores/physiology Microtubules/genetics,physiology Mitosis/genetics,physiology Models, Biological Neoplasms/etiology,genetics Saccharomyces cerevisiae/cytology,genetics,physiology Signal Transduction Spindle Apparatus/genetics,physiology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Silva P
Health Sciences Research Center, Superior Institute of Health Sciences - North, CESPU, Gandra PRD, Portugal.
Barbosa J
Nascimento A V
Faria J
Reis R
Bousbaa H
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Article Info
Journal
Cell proliferation
Abbr.
Cell Prolif
ISSN
1365-2184
DOI
10.1111/j.1365-2184.2011.00767.x
Published
2011-10-00
Pages
391-400
Language
English
Region
England
NLM ID
9105195
PMCID
PMC6496767
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2184.2011.00767.x PMC Full Text View journal details
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