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PMID: 219931 Published · ppublish English Journal Article

Drug-induced peripheral neuropathies.

British medical journal ·Vol. 1 ·No. 6164 ·1979-03-10 ·Pages 663-6

Argov Z, Mastaglia FL

Abstract

Review of the various drugs in current clinical use showed that over 50 of them may cause a purely sensory or mixed sensorimotor neuropathy. These include antimicrobials, such as isoniazid, ethambutol, ethionamide, nitrofurantoin, and metronidazole; antineoplastic agents, particularly vinca alkaloids; cardiovascular drugs, such as perhexiline and hydrallazine; hypnotics and psychotropics, notable methaqualone; antirheumatics, such as gold, indomethacin, and chloroquine; anticonvulsants, particularly phenytoin; and other drugs, including disulfiram, calcium carbimide, and dapsone. Patients receiving drug treatment who complain of paraesthesie, pain, muscle cramps, or other abnormal sensations and those without symptoms who are receiving drugs that are known or suspected to be neurotoxic should undergo neurological examination and studies of motor and sensory nerve conduction. This will allow the incidence of drug-induced peripheral neuropathy to be determined more precisely.

MeSH Terms
Anti-Infective Agents/adverse effects Anti-Inflammatory Agents, Non-Steroidal/adverse effects Anticonvulsants/adverse effects Antineoplastic Agents/adverse effects Cardiovascular Agents/adverse effects Humans Hypnotics and Sedatives/adverse effects Peripheral Nervous System Diseases/chemically induced Psychotropic Drugs/adverse effects
Chemicals
Anti-Infective Agents Anti-Inflammatory Agents, Non-Steroidal Anticonvulsants Antineoplastic Agents Cardiovascular Agents Hypnotics and Sedatives Psychotropic Drugs
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Argov Z
Mastaglia F L
References (69)
69 references, click to expand
  1. PYRIDOXAL KINASE OF HUMAN BRAIN AND ITS INHIBITION BY HYDRAZINE DERIVATIVES.
    Proc Natl Acad Sci U S A. 1959 Sep;45(9):1371-9 PMID: 16590515
  2. Peripheral neuritis due to streptomycin.
    Am Rev Respir Dis. 1960 May;81:726-8 PMID: 14406757
  3. Neurotoxicity due to thiouracil and thiourea derivatives; a case report.
    J Clin Endocrinol Metab. 1950 Jun;10(6):623-9 PMID: 15428537
  4. THE ANTIPYRIDOXINE EFFECT OF PENICILLAMINE IN MAN.
    J Clin Invest. 1964 Oct;43:1869-73 PMID: 14236210
  5. USE OF ETHOGLUCID IN TREATMENT OF ADVANCED MALIGNANT DISEASE.
    Br Med J. 1964 Apr 11;1(5388):951-3 PMID: 14107074
  6. Treatment of advanced cancer by extracorporeal perfusion and continuous intra-arterial infusion.
    Proc R Soc Med. 1962 Aug;55:643-6 PMID: 14006326
  7. Peripheral neuropathy due to ethioniamide.
    Am Rev Respir Dis. 1961 Dec;84:890-2 PMID: 14487843
  8. Optic and peripheral neuritis. Probable effect of prolonged chloramphenicol therapy.
    JAMA. 1960 Aug 13;173:1731-4 PMID: 14408026
  9. [Nervous complications of gold therapy; survey of the neurological and psychiatric symptoms; results of treatment with BAL].
    Rev Neurol (Paris). 1958 Sep;99(3):395-410 PMID: 13624417
  10. Polyneuritis occurring during hydralazine therapy; report of two cases and discussion of adverse reactions to hydralazine.
    J Am Med Assoc. 1958 May 24;167(4):427-32 PMID: 13538717
  11. Polyneuropathy as a complication of disulfiram therapy of alcoholism.
    Q J Stud Alcohol. 1956 Dec;17(4):601-7 PMID: 13389732
  12. Effects of isoniazid on pyridoxine metabolism.
    J Am Med Assoc. 1954 Dec 25;156(17):1549-52 PMID: 13211282
  13. Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.
    Am Rev Tuberc. 1954 Aug;70(2):266-73 PMID: 13180863
  14. The value of phenylbutazone in orthopaedic conditions.
    Rheumatism. 1954 Apr;10(2):44-6 PMID: 13156324
  15. Severe polyneuritis following gold therapy for rheumatoid arthritis.
    Ann Intern Med. 1950 Dec;33(6):1468-72 PMID: 14790530
  16. Peripheral neuropathy with disopyramide.
    Lancet. 1978 Feb 11;1(8059):329 PMID: 75365
  17. Peripheral-nerve lipid abnormalities in patients on perhexiline maleate.
    Lancet. 1977 Jun 11;1(8024):1258 PMID: 68353
  18. Clofibrate-induced myopathy and neuropathy.
    Lancet. 1976 Oct 23;2(7991):906 PMID: 62135
  19. Disulfiram neuropathy.
    Arch Neurol. 1978 Oct;35(10):658-60 PMID: 211996
  20. Perhexiline neuropathy: a clinicopathological study.
    Ann Neurol. 1978 Mar;3(3):259-66 PMID: 208453
  21. Clofibrate-induced complications in renal disease: a case report.
    S Afr Med J. 1977 Nov 5;52(20):806-8 PMID: 204061
  22. Peripheral neuropathy: a side effect of sulphones.
    Br Med J. 1977 May 7;1(6070):1193 PMID: 193605
  23. [Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)].
    Acta Neuropathol. 1977 Apr 29;38(1):53-9 PMID: 193347
  24. Peripheral and autonomic neuropathy after treatment with perhexiline maleate.
    Br Med J. 1977 Sep 10;2(6088):675-6 PMID: 198058
  25. Metronidazole neuropathy.
    Br Med J. 1977 Sep 3;2(6087):610-1 PMID: 198056
  26. Acute femoral neuropathy induced by oral anticoagulation.
    Dis Nerv Syst. 1976 Sep;37(9):539-41 PMID: 183940
  27. Dapsone-induced peripheral neuropathy.
    Arch Dermatol. 1976 Dec;112(12):1761-2 PMID: 188385
  28. Prevalence of latent perhexiline neuropathy.
    Br Med J. 1978 May 20;1(6123):1321-2 PMID: 647257
  29. Vincristine neuropathy. Clinical and electrophysiological observations.
    Brain. 1973;96(1):69-86 PMID: 4348690
  30. Drugs having a toxic effect on the optic nerve.
    Int Ophthalmol Clin. 1971;11(2):137-57 PMID: 4338111
  31. [Polyneuropathy following methaqualone (preliminary note)].
    Nervenarzt. 1973 Feb;44(2):104-6 PMID: 4698707
  32. [Neurologic disorders induced by Vinca rosea alkaloids (periwinkle polyneuritis)].
    Rev Neurol (Paris). 1965 Oct;113(4):464-7 PMID: 5856994
  33. Neurotoxicity of commonly used antineoplastic agents (second of two parts).
    N Engl J Med. 1974 Jul 18;291(3):127-33 PMID: 4365666
  34. Persistent neuropathy following chronic use of glutethimide.
    Clin Pharmacol Ther. 1967 Mar-Apr;8(2):283-5 PMID: 4290074
  35. Cell communication, calcium ion, and cyclic adenosine monophosphate.
    Science. 1970 Oct 23;170(3956):404-12 PMID: 4318972
  36. Effect of diphenylhydantoin on peripheral nerves in man.
    Electroencephalogr Clin Neurophysiol. 1968 Oct;25(4):411 PMID: 4176613
  37. [Letter: 7 peripheral neuropathies after treatment by perhexiline maleate].
    Nouv Presse Med. 1976 Mar 6;5(10):652-3 PMID: 1264597
  38. Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.
    Neurology. 1974 May;24(5):411-7 PMID: 4363815
  39. Letter: neuropathy due to cytosine arabinoside.
    Br Med J. 1974 Dec 14;4(5945):652-3 PMID: 4374291
  40. Ergot intoxication: historical review and description of unusual clinical manifestations.
    Ann Surg. 1974 Nov;180(5):773-9 PMID: 4371616
  41. Dapsone-induced peripheral neuropathy.
    Arch Neurol. 1972 Aug;27(2):184-5 PMID: 4339241
  42. Dapsone induced peripheral neuropathy.
    Br J Dermatol. 1972 May;86(5):521-3 PMID: 4339029
  43. Nitrofurantoin polyneuropathy.
    Neurology. 1973 May;23(5):554-9 PMID: 4349239
  44. Peripheral neuropathy with ethambutol.
    Postgrad Med J. 1972 Nov;48(565):667-70 PMID: 4346665
  45. Peripheral neuropathy after disulfiram administration.
    J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):253-9 PMID: 4328367
  46. Letter: Adverse effect of methaqualone.
    Can Med Assoc J. 1975 Mar 22;112(6):685 PMID: 1122439
  47. Chloroquine neuromyopathy.
    Ann Phys Med. 1968 Feb;9(5):189-92 PMID: 4298052
  48. Dapsone and peripheral motor neuropathy.
    Arch Dermatol. 1969 Aug;100(2):214-7 PMID: 4307884
  49. Vincristine neuropathy: an electrophysiological and histological study.
    J Neurol Neurosurg Psychiatry. 1969 Aug;32(4):297-304 PMID: 4309019
  50. Gold neuropathy.
    Neurology. 1970 May;20(5):455-8 PMID: 4314824
  51. The neuromyopathy of vincristine in man. Clinical, electrophysiological and pathological studies.
    J Neurol Sci. 1970 Feb;10(2):107-31 PMID: 4314181
  52. Peripheral neuropathy in long-term diphenylhydantoin therapy.
    Arch Neurol. 1968 Jan;18(1):69-77 PMID: 4293820
  53. Mononeuropathy multiplex as a complication of amphetamine angiitis.
    Neurology. 1975 Jun;25(6):570-2 PMID: 165440
  54. Letter: Peripheral neuropathy associated with citrated calcium carbimide.
    Lancet. 1976 Apr 24;1(7965):911-2 PMID: 58177
  55. Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis.
    Am J Med. 1973 Jan;54(1):58-72 PMID: 4581906
  56. Metronidazole for Crohn's disease.
    Lancet. 1975 Apr 5;1(7910):775-7 PMID: 48003
  57. Peripheral neuritis after methimazole therapy.
    N Y State J Med. 1972 Dec 1;72(23):2898-900 PMID: 4508415
  58. Dapsone-induced motor polyneuropathy. A complication of prolonged treatment of subcorneal pustular dermatosis.
    Arch Dermatol. 1976 Aug;112(8):1158-60 PMID: 182085
  59. Polyneuropathy after perhexiline maleate therapy.
    Br Med J. 1976 May 22;1(6020):1256 PMID: 178402
  60. Metronidazole neuropathy.
    J Neurol Neurosurg Psychiatry. 1976 Apr;39(4):403-5 PMID: 180258
  61. A clinical trial of the oral form of 4'-demethyl-epipodophyllotoxin-beta-D ethylidene glucoside (NSC 141540) VP 16-213.
    Cancer. 1975 Apr;35(4):1141-4 PMID: 163675
  62. Neural effects of nitrofurantoin.
    Arch Neurol. 1968 Jun;18(6):680-7 PMID: 4871168
  63. The ocular toxicity of ethambutol and its relation to dose.
    Ann N Y Acad Sci. 1966 Apr 20;135(2):904-9 PMID: 5220245
  64. Motor nerve conduction velocity during diphenylhydantoin intoxication.
    Acta Neurol Scand. 1971;47(3):265-71 PMID: 5096755
  65. Neurological effects of glutethimide.
    J Neurol Neurosurg Psychiatry. 1968 Dec;31(6):561-4 PMID: 5709841
  66. Neuronal changes induced by intrathecal vincristine sulfate.
    J Neuropathol Exp Neurol. 1968 Oct;27(4):645-58 PMID: 5696051
  67. [Studies on the effect and tolerance of methaqualone in neurological diseases].
    Arzneimittelforschung. 1967 Aug;17(8):1052-7 PMID: 5632061
  68. Electromyographic changes after nitrofurantoin (Furadantin) therapy in nonuremic patients.
    Neurology. 1967 Oct;17(10):1017-20 PMID: 6069603
  69. Pyridoxine-deficiency neuropathy due to hydralazine.
    N Engl J Med. 1965 Nov 25;273(22):1182-5 PMID: 5847557
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.1.6164.663
Published
1979-03-10
Pages
663-6
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1598252
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.1.6164.663 PMC Full Text
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