Abstract
B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell proliferation and survival. We found that mouse embryonic stem cells (ESCs) do not need any lamins for self-renewal and pluripotency. Although genome-wide lamin-B binding profiles correlate with reduced gene expression, such binding is not directly required for gene silencing in ESCs or trophectoderm cells. However, B-type lamins are required for proper organogenesis. Defects in spindle orientation in neural progenitor cells and migration of neurons probably cause brain disorganizations found in lamin-B null mice. Thus, our studies not only disprove several prevailing views of lamin-Bs but also establish a foundation for redefining the function of the nuclear lamina in the context of tissue building and homeostasis.
MeSH Terms
Animals
Body Size
Brain/cytology,embryology
Cell Cycle
Cell Differentiation
Cell Movement
Cells, Cultured
Chromatin/metabolism
Embryonic Development
Embryonic Stem Cells/cytology,physiology
Female
Gene Expression Regulation, Developmental
Gene Silencing
Lamin Type B/genetics,metabolism,physiology
Male
Mice
Mice, Knockout
Neural Stem Cells/cytology
Neurons/cytology
Nuclear Lamina/physiology
Organ Size
Organogenesis
Pluripotent Stem Cells/cytology,physiology
Promoter Regions, Genetic
Spindle Apparatus/physiology,ultrastructure
Transcription, Genetic
Trophoblasts/cytology
Chemicals
Chromatin
Lamin Type B
lamin B1
lamin B2
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Kim Youngjo
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA.
Sharov Alexei A
McDole Katie
Cheng Melody
Hao Haiping
Fan Chen-Ming
Gaiano Nicholas
Ko Minoru S H
Zheng Yixian
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