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PMID: 22116031 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells.

Science (New York, N.Y.) ·Vol. 334 ·No. 6063 ·2011-12-23 ·Pages 1706-10

Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan CM, Gaiano N, Ko MS, Zheng Y

Abstract

B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell proliferation and survival. We found that mouse embryonic stem cells (ESCs) do not need any lamins for self-renewal and pluripotency. Although genome-wide lamin-B binding profiles correlate with reduced gene expression, such binding is not directly required for gene silencing in ESCs or trophectoderm cells. However, B-type lamins are required for proper organogenesis. Defects in spindle orientation in neural progenitor cells and migration of neurons probably cause brain disorganizations found in lamin-B null mice. Thus, our studies not only disprove several prevailing views of lamin-Bs but also establish a foundation for redefining the function of the nuclear lamina in the context of tissue building and homeostasis.

MeSH Terms
Animals Body Size Brain/cytology,embryology Cell Cycle Cell Differentiation Cell Movement Cells, Cultured Chromatin/metabolism Embryonic Development Embryonic Stem Cells/cytology,physiology Female Gene Expression Regulation, Developmental Gene Silencing Lamin Type B/genetics,metabolism,physiology Male Mice Mice, Knockout Neural Stem Cells/cytology Neurons/cytology Nuclear Lamina/physiology Organ Size Organogenesis Pluripotent Stem Cells/cytology,physiology Promoter Regions, Genetic Spindle Apparatus/physiology,ultrastructure Transcription, Genetic Trophoblasts/cytology
Chemicals
Chromatin Lamin Type B lamin B1 lamin B2
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Kim Youngjo
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA.
Sharov Alexei A
McDole Katie
Cheng Melody
Hao Haiping
Fan Chen-Ming
Gaiano Nicholas
Ko Minoru S H
Zheng Yixian
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2011-12-23
Epub
2011-00-24
Pages
1706-10
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3306219
Subset
IM
Grants
NIAMS NIH HHS · R01 AR060042-02 · United States
NIAMS NIH HHS · R01 AR060042 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM056312 · United States
Intramural NIH HHS · United States
NIGMS NIH HHS · R01 GM 56312 · United States
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